methyl [5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate

Base Information

Chemical Name:methyl [5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate
CAS No.:871266-65-8
Molecular Formula:C₂₈H₃₁N₅O₆S
Molecular Weight:565.65
Hs Code.:

Synonyms:methyl [5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate

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Chemical Property of methyl [5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate

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Technology Process of methyl [5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate

There total 17 articles about methyl [5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871266-64-7
methyl [5'-N-tert-butylsulfamoyl-5-formyl-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate

: 3,4-diaminobenzamidine monohydrochloride

: 871266-65-8
methyl [5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate

Guidance literature:: methyl [5'-N-tert-butylsulfamoyl-5-formyl-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate; With sodium hydrogensulfite; In water; isopropyl alcohol; at 60 ℃; for 2.5h;

3,4-diaminobenzamidine monohydrochloride; In water; isopropyl alcohol; for 18h;

Reference yield:

: C₂₁H₂₆NO₁₀S₂^(1-)*Na⁽¹⁺⁾

: 3,4-diaminobenzamidine monohydrochloride

: 871266-65-8
methyl [5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate

Guidance literature:: With oxygen; In water; isopropyl alcohol; at 60 ℃; for 19h;

Reference yield:

: 1576243-71-4
sodium salt of [4-hydroxy-3-(hydroxysulfomethyl)phenyl]acetic acid methyl ester

: 871266-65-8
methyl [5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate

Guidance literature:: Multi-step reaction with 7 steps

1: water; phosphoric acid

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 4 h / 5 - 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diisopropylamine / tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

5: water; hydrogenchloride / methanol / 20 - 25 °C

6: sodium metabisulfite / isopropyl alcohol / 2.5 h / 60 °C

7: oxygen / water; isopropyl alcohol / 19 h / 60 °C

With hydrogenchloride; sodium metabisulfite; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; phosphoric acid; water; oxygen; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;