3',5'-DIFLUOROBIPHENYL-4-CARBALDEHYDE

Base Information

• Chemical Name: 3',5'-DIFLUOROBIPHENYL-4-CARBALDEHYDE
• CAS No.: 221018-03-7
• Molecular Formula: C₁₃H₈F₂O
• Molecular Weight: 218.203
• Mol file: 221018-03-7.mol

Synonyms:4-(3,5-Difluorophenyl)benzaldehyde;3',5'-Difluorobiphenyl-4-carbaldehyde;

Chemical Property of 3',5'-DIFLUOROBIPHENYL-4-CARBALDEHYDE

Chemical Property:

• Boiling Point: 322.8 °C at 760 mmHg
• Flash Point: 123.8 °C
• PSA: 17.07000
• Density: 1.248 g/cm³
• LogP: 3.44430

Purity/Quality:

98%min ^*data from raw suppliers

3',5'-Difluoro-[1,1'-biphenyl]-4-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3',5'-DIFLUOROBIPHENYL-4-CARBALDEHYDE

There total 5 articles about 3',5'-DIFLUOROBIPHENYL-4-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-bromo-benzaldehyde (1122-91-4) + 3,5-difluorophenylboronic acid (156545-07-2) → 3',5'‐difluoro‐[1,1'‐biphenyl]‐4‐carbaldehyde (221018-03-7)

Guidance literature:

With potassium carbonate; In ethanol; water; at 60 ℃; for 2h;

DOI:10.1039/c5cy00821b

Reference yield: 83.0%

4-chlorobenzaldehyde (104-88-1) + 3,5-difluorophenylboronic acid (156545-07-2) → 3',5'‐difluoro‐[1,1'‐biphenyl]‐4‐carbaldehyde (221018-03-7)

Guidance literature:

With potassium phosphate monohydrate; 2‐(dicyclohexylphosphino)‐N,N‐diisopropyl‐5,6‐dimethyl‐1H‐benzo[d]imidazole‐1‐carboxamide; palladium diacetate; In tetrahydrofuran; at 110 ℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.organomet.0c00816

Reference yield: 65.0%

3,5-difluorobromobenzene (461-96-1) + 4-formylphenylboronic acid, (87199-17-5) → 3',5'‐difluoro‐[1,1'‐biphenyl]‐4‐carbaldehyde (221018-03-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; at 90 ℃; for 13h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03866

upstream raw materials:

4-bromo-benzaldehyde

3,5-difluorophenylboronic acid

p-(iodophenyl)carboxaldehyde

4-chlorobenzaldehyde

Refernces

• 1、 Wong, Shun Man,Choy, Pui Ying,Zhao, Qingyang,Yuen, On Ying,Yeung, Chung Chiu,So, Chau Ming,Kwong, Fuk Yee. "Design of Benzimidazolyl Phosphines Bearing AlterableP,OorP,N-Coordination: Synthesis, Characterization, and Insights into Their Reactivity". supporting information. p. 2265 - 2271. Retrieved 2021/05/05.
• 2、 Gholinejad, Mohammad,Razeghi, Mehran,Ghaderi, Arash,Biji, Pullithadathil. "Palladium supported on phosphinite functionalized Fe3O4 nanoparticles as a new magnetically separable catalyst for Suzuki-Miyaura coupling reactions in aqueous media". . p. 3117 - 3127. Retrieved 2016/05/24.