5-amino-N-(4-chloro-3-fluorophenyl)-3-methyl-1,2-thiazole-4-carboxamide

Base Information

Chemical Name:5-amino-N-(4-chloro-3-fluorophenyl)-3-methyl-1,2-thiazole-4-carboxamide
CAS No.:1621367-85-8
Molecular Formula:C₁₁H₉ClFN₃OS
Molecular Weight:285.729
Hs Code.:

Synonyms:5-amino-N-(4-chloro-3-fluorophenyl)-3-methyl-1,2-thiazole-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-amino-N-(4-chloro-3-fluorophenyl)-3-methyl-1,2-thiazole-4-carboxamide

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Technology Process of 5-amino-N-(4-chloro-3-fluorophenyl)-3-methyl-1,2-thiazole-4-carboxamide

There total 3 articles about 5-amino-N-(4-chloro-3-fluorophenyl)-3-methyl-1,2-thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 367-22-6
4-chloro-3-fluoroaniline

: 22131-51-7
5-amino-3-methyl-1,2-thiazole-4-carboxylic acid

: 1621367-85-8
5-amino-N-(4-chloro-3-fluorophenyl)-3-methyl-1,2-thiazole-4-carboxamide

Guidance literature:: 5-amino-3-methyl-1,2-thiazole-4-carboxylic acid; With thionyl chloride; at 80 ℃; for 2h;

4-chloro-3-fluoroaniline; With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield: 21.0%

: 367-22-6
4-chloro-3-fluoroaniline

: 154807-47-3
5-amino-3-methyl-4-isothiazolecarboxylic acid chloride

: 1621367-85-8
5-amino-N-(4-chloro-3-fluorophenyl)-3-methyl-1,2-thiazole-4-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 22131-51-7
5-amino-3-methyl-1,2-thiazole-4-carboxylic acid

: 1621367-85-8
5-amino-N-(4-chloro-3-fluorophenyl)-3-methyl-1,2-thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / 100 °C

2: triethylamine / tetrahydrofuran / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;