(2R,3S)-2,3-bis-(tert-butyl-dimethylsilanyloxy)-3-[(R)-1-(2-nitrobenzenesulfonyl)-1,2,5,6-tetrahydropyridin-2-yl]-propan-1-ol

Base Information

Chemical Name:(2R,3S)-2,3-bis-(tert-butyl-dimethylsilanyloxy)-3-[(R)-1-(2-nitrobenzenesulfonyl)-1,2,5,6-tetrahydropyridin-2-yl]-propan-1-ol
CAS No.:501416-16-6
Molecular Formula:C₂₆H₄₆N₂O₇SSi₂
Molecular Weight:586.897
Hs Code.:

Synonyms:(2R,3S)-2,3-bis-(tert-butyl-dimethylsilanyloxy)-3-[(R)-1-(2-nitrobenzenesulfonyl)-1,2,5,6-tetrahydropyridin-2-yl]-propan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-2,3-bis-(tert-butyl-dimethylsilanyloxy)-3-[(R)-1-(2-nitrobenzenesulfonyl)-1,2,5,6-tetrahydropyridin-2-yl]-propan-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,3S)-2,3-bis-(tert-butyl-dimethylsilanyloxy)-3-[(R)-1-(2-nitrobenzenesulfonyl)-1,2,5,6-tetrahydropyridin-2-yl]-propan-1-ol

There total 10 articles about (2R,3S)-2,3-bis-(tert-butyl-dimethylsilanyloxy)-3-[(R)-1-(2-nitrobenzenesulfonyl)-1,2,5,6-tetrahydropyridin-2-yl]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 301805-19-6
(3R,4S)-bis-(tert-butyl-dimethylsilanyloxy)-4-[(R)-1-(2-nitrobenzenesulfonyl)-1,2,5,6-tetrahydropyridin-2-yl]-butane-1,2-diol

: 501416-16-6
(2R,3S)-2,3-bis-(tert-butyl-dimethylsilanyloxy)-3-[(R)-1-(2-nitrobenzenesulfonyl)-1,2,5,6-tetrahydropyridin-2-yl]-propan-1-ol

Guidance literature:: (3R,4S)-bis-(tert-butyl-dimethylsilanyloxy)-4-[(R)-1-(2-nitrobenzenesulfonyl)-1,2,5,6-tetrahydropyridin-2-yl]-butane-1,2-diol; With sodium periodate; In methanol; at 0 ℃; for 0.5h;

With sodium tetrahydroborate; In methanol; water; at 0 ℃; for 0.05h;
DOI:10.1016/S0040-4020(02)00832-3

Reference yield:

: 301805-13-0
(-)-N-(but-3-enyl)-N-{(1R,4R,5S)-4,5-bis-(tert-butyldimethylsilanyloxy)cyclopent-2-enyl}-2-nitrobenzenesulfonamide

: 501416-16-6
(2R,3S)-2,3-bis-(tert-butyl-dimethylsilanyloxy)-3-[(R)-1-(2-nitrobenzenesulfonyl)-1,2,5,6-tetrahydropyridin-2-yl]-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / ethylene; Cl₂(PCy₃)2Ru=CHPh / CH₂Cl₂

2.1: 80 percent / NMO; K₂OsO₄*2H₂O / acetone; H₂O / 20 °C

3.1: NaIO₄ / methanol / 0.5 h / 0 °C

3.2: 99 percent / NaBH₄ / methanol; H₂O / 0.05 h / 0 °C

With potassium osmate(VI); sodium periodate; Grubbs catalyst first generation; N-methyl-2-indolinone; ethene; In methanol; dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(02)00832-3