2-[N-methyl-N-{3'-(3-chlorophenyl)prop-2'-ynyl}]aminophenyl p-toluene sulfonate

Base Information

Chemical Name:2-[N-methyl-N-{3'-(3-chlorophenyl)prop-2'-ynyl}]aminophenyl p-toluene sulfonate
CAS No.:326598-36-1
Molecular Formula:C₂₃H₂₀ClNO₃S
Molecular Weight:425.936
Hs Code.:

Synonyms:2-[N-methyl-N-{3'-(3-chlorophenyl)prop-2'-ynyl}]aminophenyl p-toluene sulfonate

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Chemical Property of 2-[N-methyl-N-{3'-(3-chlorophenyl)prop-2'-ynyl}]aminophenyl p-toluene sulfonate

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Technology Process of 2-[N-methyl-N-{3'-(3-chlorophenyl)prop-2'-ynyl}]aminophenyl p-toluene sulfonate

There total 5 articles about 2-[N-methyl-N-{3'-(3-chlorophenyl)prop-2'-ynyl}]aminophenyl p-toluene sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 625-99-0
3-iodochlorobenzene

: 219599-04-9
2-(N-methyl-N-prop-2'-ynylamino)phenyl p-toluenesulfonate

: 326598-36-1
2-[N-methyl-N-{3'-(3-chlorophenyl)prop-2'-ynyl}]aminophenyl p-toluene sulfonate

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 20 ℃; for 16h;
DOI:10.1021/jo000826j

Reference yield:

: 1216-96-2
2-aminophenyl p-toluenesulfonate

: 326598-36-1
2-[N-methyl-N-{3'-(3-chlorophenyl)prop-2'-ynyl}]aminophenyl p-toluene sulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃ / dimethylformamide / 16 h / 20 °C

1.2: 58 percent / dimethylformamide / 48 h / 80 °C

2.1: K₂CO₃ / dimethylformamide / 16 h / 20 °C

2.2: 83 percent / dimethylformamide / 48 h / 80 °C

3.1: 95 percent / CuI; Et₃N / (PPh₃)2PdCl₂ / 16 h / 20 °C

With copper(l) iodide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide;
DOI:10.1021/jo000826j

Reference yield:

: 95-55-6
2-amino-phenol

: 326598-36-1
2-[N-methyl-N-{3'-(3-chlorophenyl)prop-2'-ynyl}]aminophenyl p-toluene sulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / CH₂Cl₂

2.1: K₂CO₃ / dimethylformamide / 16 h / 20 °C

2.2: 58 percent / dimethylformamide / 48 h / 80 °C

3.1: K₂CO₃ / dimethylformamide / 16 h / 20 °C

3.2: 83 percent / dimethylformamide / 48 h / 80 °C

4.1: 95 percent / CuI; Et₃N / (PPh₃)2PdCl₂ / 16 h / 20 °C

With copper(l) iodide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo000826j