5-bromo-3-(4-benzylpiperazin-1-yl)-7-(trifluoromethyl)quinoline

Base Information

Chemical Name:5-bromo-3-(4-benzylpiperazin-1-yl)-7-(trifluoromethyl)quinoline
CAS No.:1332492-92-8
Molecular Formula:C₂₁H₁₉BrF₃N₃
Molecular Weight:450.301
Hs Code.:

Synonyms:5-bromo-3-(4-benzylpiperazin-1-yl)-7-(trifluoromethyl)quinoline

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Chemical Property of 5-bromo-3-(4-benzylpiperazin-1-yl)-7-(trifluoromethyl)quinoline

Chemical Property:

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Technology Process of 5-bromo-3-(4-benzylpiperazin-1-yl)-7-(trifluoromethyl)quinoline

There total 7 articles about 5-bromo-3-(4-benzylpiperazin-1-yl)-7-(trifluoromethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1250224-63-5
2-(4-benzylpiperazin-1-yl)acetaldehyde

: 1332492-86-0
2-amino-6-bromo-4-(trifluoromethyl)benzaldehyde

: 1332492-92-8
5-bromo-3-(4-benzylpiperazin-1-yl)-7-(trifluoromethyl)quinoline

Guidance literature:: With sodium hydroxide; In ethanol; at 78 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c1ob05830d

Reference yield:

: 955978-78-6
2-methyl-1,3-dinitro-5-(trifluoromethyl)benzene

: 1332492-92-8
5-bromo-3-(4-benzylpiperazin-1-yl)-7-(trifluoromethyl)quinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: diammonium sulfide / ethanol / 8.5 h / Reflux; Inert atmosphere

2.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 100 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 16 h / 135 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: iron; ammonium chloride / ethanol; water / Inert atmosphere; Reflux

5.1: sodium hydroxide / ethanol / 1 h / 78 °C / Inert atmosphere

With diammonium sulfide; hydrogen bromide; iron; ammonium chloride; N,N-dimethyl-formamide dimethyl acetal; sodium hydroxide; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; 5.1: Friedlaender synthesis;
DOI:10.1039/c1ob05830d

Reference yield:

: 239079-89-1
1-bromo-2-methyl-3-nitro-5-(trifluoromethyl)benzene

: 1332492-92-8
5-bromo-3-(4-benzylpiperazin-1-yl)-7-(trifluoromethyl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 16 h / 135 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: iron; ammonium chloride / ethanol; water / Inert atmosphere; Reflux

3.1: sodium hydroxide / ethanol / 1 h / 78 °C / Inert atmosphere

With iron; ammonium chloride; N,N-dimethyl-formamide dimethyl acetal; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; 3.1: Friedlaender synthesis;
DOI:10.1039/c1ob05830d