2-BROMO-6-NITRO-4-TRIFLUOROMETHYLTOLUENE

Base Information

• Chemical Name: 2-BROMO-6-NITRO-4-TRIFLUOROMETHYLTOLUENE
• CAS No.: 239079-89-1
• Molecular Formula: C8H5 Br F3 N O2
• Molecular Weight: 284.03
• Mol file: 239079-89-1.mol

Synonyms:2-BROMO-6-NITRO-4-TRIFLUOROMETHYLTOLUENE

Chemical Property of 2-BROMO-6-NITRO-4-TRIFLUOROMETHYLTOLUENE

Chemical Property:

• Boiling Point: 239.9±35.0 °C(Predicted)
• PSA: 45.82000
• Density: 1.698±0.06 g/cm3(Predicted)
• LogP: 4.20770

Purity/Quality:

98.5% ^*data from raw suppliers

2-BROMO-6-NITRO-4-TRIFLUOROMETHYLTOLUENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-6-NITRO-4-TRIFLUOROMETHYLTOLUENE

There total 2 articles about 2-BROMO-6-NITRO-4-TRIFLUOROMETHYLTOLUENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-methyl-3-nitro-5-(trifluoromethyl)aniline (1332492-84-8) → 1-bromo-2-methyl-3-nitro-5-(trifluoromethyl)benzene (239079-89-1)

Guidance literature:

2-methyl-3-nitro-5-(trifluoromethyl)aniline; With hydrogen bromide; sodium nitrite; In water; at 0 ℃; for 0.5h; Inert atmosphere;

With copper(I) bromide; at 100 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c1ob05830d

Reference yield:

2-methyl-1,3-dinitro-5-(trifluoromethyl)benzene (955978-78-6) → 1-bromo-2-methyl-3-nitro-5-(trifluoromethyl)benzene (239079-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diammonium sulfide / ethanol / 8.5 h / Reflux; Inert atmosphere

2.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 100 °C / Inert atmosphere

With diammonium sulfide; hydrogen bromide; sodium nitrite; In ethanol; water;

DOI:10.1039/c1ob05830d

Reference yield: 55.0%

1-bromo-2-methyl-3-nitro-5-(trifluoromethyl)benzene (239079-89-1) → 2-bromo-6-nitro-4-(trifluoromethyl)benzaldehyde (1332492-85-9)

Guidance literature:

1-bromo-2-methyl-3-nitro-5-(trifluoromethyl)benzene; With N,N-dimethyl-formamide dimethyl acetal; In N,N-dimethyl-formamide; at 135 ℃; for 16h; Inert atmosphere;

With sodium periodate; In water; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c1ob05830d

upstream raw materials:

2-methyl-1,3-dinitro-5-(trifluoromethyl)benzene

2-methyl-3-nitro-5-(trifluoromethyl)aniline

Downstream raw materials:

Zgwatinib

5-bromo-3-(4-benzylpiperazin-1-yl)-7-(trifluoromethyl)quinoline

5-bromo-3-(4-phenylpiperazin-1-yl)-7-(trifluoromethyl)quinoline

2-bromo-6-nitro-4-(trifluoromethyl)benzaldehyde

Refernces