Disuccinimidyl glutarate

Base Information

• Chemical Name: Disuccinimidyl glutarate
• CAS No.: 79642-50-5
• Molecular Formula: C13H14N2O8
• Molecular Weight: 326.263
• Hs Code.: 29280000
• DSSTox Substance ID: DTXSID30403242
• Nikkaji Number: J1.043.902G
• Wikidata: Q72469950
• Mol file: 79642-50-5.mol

Synonyms:disuccinimidyl glutarate

Chemical Property of Disuccinimidyl glutarate

Chemical Property:

• Melting Point: 168-172 °C
• Boiling Point: 485.1 °C at 760 mmHg
• Flash Point: 247.2 °C
• PSA: 127.36000
• Density: 1.53 g/cm³
• LogP: -0.75310
• Storage Temp.: −20°C
• Sensitive.: Moisture Sensitive
• Solubility.: DMSO (Sparingly, Sonicated), Methanol (Slightly, Sonicated)
• Water Solubility.: Soluble in dimethylsulfoxide and dimethylformamide. Partially soluble in water.
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 8
• Exact Mass: 326.07501541
• Heavy Atom Count: 23
• Complexity: 503

Purity/Quality:

99%, ^*data from raw suppliers

DisuccinimidylGlutarate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

• Canonical SMILES: C1CC(=O)N(C1=O)OC(=O)CCCC(=O)ON2C(=O)CCC2=O
• Description: Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinking agent that contains amine-reactive N-hydroxysuccinimide (NHS) ester groups at each end. DSG is membrane-permeable and non-cleavable. DSG can be combined with formaldehyde fixation to improve the detection of specific protein-DNA complexes.
• Uses: Disuccinimidyl glutarate is used as a membrane-soluble, amine-reactive N-hydroxysuccinamide ester-based homobifunctional crosslinking reagent. It is a homobifunctionla cross-linking reagent, for ex. isolation of the insulin receptor.

Technology Process of Disuccinimidyl glutarate

There total 3 articles about Disuccinimidyl glutarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + gloutaric dichloride (2873-74-7) → disuccinimidyl glutarate (79642-50-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1039/b613469f

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 1,5-pentanedioic acid (110-94-1) → disuccinimidyl glutarate (79642-50-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetone; at 25 ℃; for 24h;

DOI:10.1515/chempap-2015-0226

Reference yield:

→ disuccinimidyl glutarate (79642-50-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

gloutaric dichloride

1,5-pentanedioic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 79642-50-5 DISUCCINIMIDYL GLUTARATE

Send

Send

Metric Ton KG G Pound L ML

Send

Send