3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER

Base Information

• Chemical Name: 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER
• CAS No.: 24922-01-8
• Molecular Formula: C9H14 O3
• Molecular Weight: 170.208
• Hs Code.: 2918300090
• Mol file: 24922-01-8.mol

Synonyms:Cyclobutanepropionicacid, b-oxo-, ethyl ester (8CI); Ethyl3-cyclobutyl-3-oxopropanoate

Chemical Property of 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0526mmHg at 25°C
• Boiling Point: 234.5°C at 760 mmHg
• PKA: 10.51±0.20(Predicted)
• Flash Point: 95.7°C
• PSA: 43.37000
• Density: 1.096g/cm³
• LogP: 1.30880
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 3-cyclobutyl-3-oxopropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER

There total 7 articles about 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl potassium malonate (6148-64-7) + Cyclobutanecarbonyl chloride (5006-22-4) → ethyl 3-cyclobutyl-3-oxopropanoate (24922-01-8)

Guidance literature:

ethyl potassium malonate; With triethylamine; magnesium chloride; In acetonitrile; at 10 - 20 ℃; for 2.5h; Inert atmosphere;

Cyclobutanecarbonyl chloride; In acetonitrile; at 0 - 20 ℃; for 19h;

With hydrogenchloride; In water; ethyl acetate; pH=5;

Reference yield: 88.0%

Cyclobutanecarboxylic acid (3721-95-7) + ethyl potassium malonate (6148-64-7) → ethyl 3-cyclobutyl-3-oxopropanoate (24922-01-8)

Guidance literature:

Cyclobutanecarboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 60 ℃; for 1h;

ethyl potassium malonate; With magnesium chloride; In tetrahydrofuran; at 60 ℃; for 1h;

Reference yield: 78.0%

hydrogen ethyl malonate (1071-46-1) + Cyclobutanecarbonyl chloride (5006-22-4) → ethyl 3-cyclobutyl-3-oxopropanoate (24922-01-8)

Guidance literature:

With [2,2]bipyridinyl; n-butyllithium; In tetrahydrofuran; hexanes; at -55 - 20 ℃;

upstream raw materials:

2-cyclobutanecarbonyl-3-oxo-butyric acid ethyl ester

hydrogen ethyl malonate

Cyclobutanecarbonyl chloride

ethyl potassium malonate

Downstream raw materials:

ethyl 3-cyclobutyl-2-[(3,4-dichlorophenyl)methyl]-3-oxopropanoate

ethyl 2-[(3-chlorophenyl)methyl]-3-cyclobutyl-3-oxopropanoate

ethyl 3-cyclobutyl-2-[(3,4-difluorophenyl)methyl]-3-oxopropanoate

ethyl 3-cyclobutyl-2-{[4-fluoro-3-(trifluoromethyl)phenyl]methyl}-3-oxopropanoate

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