4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-N-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-ylmethyl)-2-methyl-benzamide

Base Information

Chemical Name:4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-N-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-ylmethyl)-2-methyl-benzamide
CAS No.:1309958-10-8
Molecular Formula:C₂₄H₂₄Cl₂F₃N₃O₄S
Molecular Weight:578.439
Hs Code.:

Synonyms:4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-N-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-ylmethyl)-2-methyl-benzamide

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Chemical Property of 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-N-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-ylmethyl)-2-methyl-benzamide

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Technology Process of 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-N-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-ylmethyl)-2-methyl-benzamide

There total 7 articles about 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-N-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-ylmethyl)-2-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazol-3-yl]-2-methylbenzoyl chloride

: 1309959-01-0
C-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-yl)-methylamine

: 1309958-10-8
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-N-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-ylmethyl)-2-methyl-benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 864725-62-2
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

: 1309959-01-0
C-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-yl)-methylamine

: 1309958-10-8
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-N-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-ylmethyl)-2-methyl-benzamide

Guidance literature:: 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 18h;

C-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-yl)-methylamine; With triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 1309958-97-1
N-(3-Benzyloxy-2-hydroxy-propyl)-N-ethyl-methanesulfonamide

: 1309958-10-8
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-N-(2-ethyl-1,1-dioxo-1λ6-isothiazolidin-4-ylmethyl)-2-methyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; benzenesulfonyl chloride / 24 h / 50 °C

1.2: 2 h / -78 - 0 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 24 h

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

4.1: hydrazine hydrate / ethanol / Reflux

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

5.2: 24 h / 20 °C

With pyridine; oxalyl dichloride; di-isopropyl azodicarboxylate; hydrogen; hydrazine hydrate; N,N-dimethyl-formamide; benzenesulfonyl chloride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;