4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

Base Information

• Chemical Name: 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid
• CAS No.: 864725-62-2
• Molecular Formula: C₁₈H₁₂Cl₂F₃NO₃
• Molecular Weight: 418.199
• Mol file: 864725-62-2.mol

Synonyms:4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

Chemical Property of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

There total 17 articles about 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid methyl ester (864736-32-3) → 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid (864725-62-2)

Guidance literature:

4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid methyl ester; With water; potassium hydroxide; In tetrahydrofuran; methanol; for 0.5h; Reflux;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=1;

Reference yield: 97.0%

4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl]-2-methylbenzoic acid (1095275-26-5) → 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid (864725-62-2)

Guidance literature:

With hydroxylamine; sodium hydroxide; tetrabutylammomium bromide; In water; toluene; Product distribution / selectivity;

Reference yield: 68.0%

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (864725-22-4) + C9H9NO4 → 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid (864725-62-2)

Guidance literature:

With dmap; di-tert-butyl dicarbonate; triethylamine; In toluene; at 20 ℃; for 24h;

upstream raw materials:

4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoic acid tert-butyl ester

carbon monoxide

4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl]-2-methylbenzoic acid

4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid methyl ester

Downstream raw materials:

4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-iodo-6-methyl-benzoic acid

N-cyanomethyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzamide

2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole-4-carboxylic acid ethyl ester

2-({4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoylamino}methyl)-4,5-dihydrothiazole