N-(5-(4-(difluoromethyl)-3-fluorophenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

Base Information

Chemical Name:N-(5-(4-(difluoromethyl)-3-fluorophenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine
CAS No.:1354286-94-4
Molecular Formula:C₃₁H₂₄F₅N₅O
Molecular Weight:577.556
Hs Code.:

Synonyms:N-(5-(4-(difluoromethyl)-3-fluorophenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

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Chemical Property of N-(5-(4-(difluoromethyl)-3-fluorophenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

Chemical Property:

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Technology Process of N-(5-(4-(difluoromethyl)-3-fluorophenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

There total 6 articles about N-(5-(4-(difluoromethyl)-3-fluorophenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310949-75-7
2-(4-(difluoromethyl)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1354288-75-7
5,7-difluoro-N-(5-iodo-2-morpholinopyridin-4-yl)-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

: 1354286-94-4
N-(5-(4-(difluoromethyl)-3-fluorophenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

Guidance literature:: With potassium phosphate; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 19h; Inert atmosphere;

Reference yield:

: 35980-77-9
2-morpholinopyridine-4-amine

: 1354286-94-4
N-(5-(4-(difluoromethyl)-3-fluorophenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium iodide; iodine; sodium carbonate / water / 2 h / Reflux

2: sodium hydride / 1,2-dimethoxyethane / 103 h / 20 - 70 °C

3: tricyclohexylphosphine; potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 19 h / 90 °C / Inert atmosphere

With potassium phosphate; iodine; sodium hydride; sodium carbonate; potassium iodide; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 848579-81-7
5-iodo-2-morpholin-4-yl-pyridin-4-ylamine

: 1354286-94-4
N-(5-(4-(difluoromethyl)-3-fluorophenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / 1,2-dimethoxyethane / 103 h / 20 - 70 °C

2: tricyclohexylphosphine; potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 19 h / 90 °C / Inert atmosphere

With potassium phosphate; sodium hydride; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; water;