(R)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylthio)phenoxy)phosphoryl)oxy)phenyl)propanoate

Base Information

• Chemical Name: (R)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylthio)phenoxy)phosphoryl)oxy)phenyl)propanoate
• CAS No.: 1412427-14-5
• Molecular Formula: C₂₃H₃₀NO₇PS
• Molecular Weight: 495.533
• Mol file: 1412427-14-5.mol

Synonyms:(R)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylthio)phenoxy)phosphoryl)oxy)phenyl)propanoate

Chemical Property of (R)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylthio)phenoxy)phosphoryl)oxy)phenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylthio)phenoxy)phosphoryl)oxy)phenyl)propanoate

There total 6 articles about (R)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylthio)phenoxy)phosphoryl)oxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-hydroxythioanisole (1073-72-9) + (Sp)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylsulfonyl)phenoxy)phosphoryl)oxy)phenyl)propanoate (1412427-17-8) → (R)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylthio)phenoxy)phosphoryl)oxy)phenyl)propanoate (1412427-14-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 48h; Inert atmosphere;

Reference yield:

ethyl 3-(2-hydroxyphenyl)propanoate (20921-04-4) → (R)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylthio)phenoxy)phosphoryl)oxy)phenyl)propanoate (1412427-14-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine; trichlorophosphate / diethyl ether / 18 h / -78 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 7.33 h / -78 - 0 °C / Inert atmosphere

2.2: 12 h / -78 - 20 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 48 h / 0 - 20 °C / Inert atmosphere

With triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In diethyl ether; dichloromethane;

Reference yield:

4-hydroxythioanisole (1073-72-9) + (Sp)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylsulfonyl)phenoxy)phosphoryl)oxy)phenyl)propanoate (1412427-17-8) + ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylsulfonyl)phenoxy)phosphoryl)oxy)phenyl)propanoate (1412427-16-7) → (S)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylthio)phenoxy)phosphoryl)oxy)phenyl)propanoate (1412427-15-6) + (R)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylthio)phenoxy)phosphoryl)oxy)phenyl)propanoate (1412427-14-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 48h; Inert atmosphere;

upstream raw materials:

4-hydroxythioanisole

(Sp)-ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylsulfonyl)phenoxy)phosphoryl)oxy)phenyl)propanoate

ethyl 3-(2-(((((S)-1-ethoxy-1-oxopropan-2-yl)amino)(4-(methylsulfonyl)phenoxy)phosphoryl)oxy)phenyl)propanoate

C₆H₄(CH₂CH₂C(O)O)