(Z)-3-(2',4'-dimethoxypyrimidin-5'-yl)methylidene-N-m-chlorophenyl isoindolin-1-one

Base Information

Chemical Name:(Z)-3-(2',4'-dimethoxypyrimidin-5'-yl)methylidene-N-m-chlorophenyl isoindolin-1-one
CAS No.:202004-88-4
Molecular Formula:C₂₁H₁₆ClN₃O₃
Molecular Weight:393.829
Hs Code.:

Synonyms:(Z)-3-(2',4'-dimethoxypyrimidin-5'-yl)methylidene-N-m-chlorophenyl isoindolin-1-one

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Chemical Property of (Z)-3-(2',4'-dimethoxypyrimidin-5'-yl)methylidene-N-m-chlorophenyl isoindolin-1-one

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Technology Process of (Z)-3-(2',4'-dimethoxypyrimidin-5'-yl)methylidene-N-m-chlorophenyl isoindolin-1-one

There total 4 articles about (Z)-3-(2',4'-dimethoxypyrimidin-5'-yl)methylidene-N-m-chlorophenyl isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 83355-88-8
(2,4-dimethoxy-5-pyrimidinyl) acetylene

: 197141-50-7
N-(3-chlorophenyl)-o-iodobenzamide

: 202004-88-4
(Z)-3-(2',4'-dimethoxypyrimidin-5'-yl)methylidene-N-m-chlorophenyl isoindolin-1-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 16h;
DOI:10.1055/s-1997-1049

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 202004-88-4
(Z)-3-(2',4'-dimethoxypyrimidin-5'-yl)methylidene-N-m-chlorophenyl isoindolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: PCl₅ / 2 h / 80 °C

2: benzene

3: 81 percent / bis(triphenylphosphine)palladium(II) chloride; copper(I) iodide; triethylamine / dimethylformamide / 15 h / 80 - 85 °C

With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; phosphorus pentachloride; triethylamine; In N,N-dimethyl-formamide; benzene; 1: Chlorination / 2: Acylation / 3: Condensation;
DOI:10.1016/S0040-4020(00)00359-8

Reference yield:

: 609-67-6
2-Iodobenzoyl chloride

: 202004-88-4
(Z)-3-(2',4'-dimethoxypyrimidin-5'-yl)methylidene-N-m-chlorophenyl isoindolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: benzene

2: 81 percent / bis(triphenylphosphine)palladium(II) chloride; copper(I) iodide; triethylamine / dimethylformamide / 15 h / 80 - 85 °C

With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; triethylamine; In N,N-dimethyl-formamide; benzene; 1: Acylation / 2: Condensation;
DOI:10.1016/S0040-4020(00)00359-8