C₁₈H₁₂FNO₂

Base Information

Chemical Name:C₁₈H₁₂FNO₂
CAS No.:1367126-25-7
Molecular Formula:C₁₈H₁₂FNO₂
Molecular Weight:293.297
Hs Code.:

C<sub>18</sub>H<sub>12</sub>FNO<sub>2</sub>

Synonyms:C₁₈H₁₂FNO₂

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Chemical Property of C₁₈H₁₂FNO₂

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Technology Process of C₁₈H₁₂FNO₂

There total 6 articles about C₁₈H₁₂FNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 1355052-34-4
2-(4-(4-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1367126-25-7
C₁₈H₁₂FNO₂

Guidance literature:: With tetrabutyl ammonium fluoride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; at 60 ℃; for 20h; Inert atmosphere;

Reference yield:

: 371-41-5
4-Fluorophenol

: 1367126-25-7
C₁₈H₁₂FNO₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere

3.1: sulfuric acid / 1,2-dimethoxyethane; water

3.2: 0.83 h / 0 - 5 °C

3.3: 0.5 h / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

4.2: 18 h / 90 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere

With sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1367126-25-7
C₁₈H₁₂FNO₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere

3.1: sulfuric acid / 1,2-dimethoxyethane; water

3.2: 0.83 h / 0 - 5 °C

3.3: 0.5 h / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

4.2: 18 h / 90 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere

With sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;