Benzofuran-4-amine

Base Information

• Chemical Name: Benzofuran-4-amine
• CAS No.: 412336-07-3
• Molecular Formula: C8H7NO
• Molecular Weight: 133.14728
• Hs Code.: 2932999099
• European Community (EC) Number: 875-143-2
• DSSTox Substance ID: DTXSID60465333
• Nikkaji Number: J2.357.969C
• Wikidata: Q82291186
• Mol file: 412336-07-3.mol

Synonyms:Benzofuran-4-amine;1-Benzofuran-4-amine;412336-07-3;4-AMINOBENZOFURAN;4-Benzofuranamine;SCHEMBL824913;DTXSID60465333;OCZGGFAZAPGFMC-UHFFFAOYSA-N;MFCD09038105;AKOS006330399;MB06879;AS-36195;CS-0208605;EN300-102702;J-519744

Chemical Property of Benzofuran-4-amine

Chemical Property:

• Boiling Point: 259.8 °C at 760 mmHg
• PKA: 3.68±0.10(Predicted)
• Flash Point: 110.9 °C
• PSA: 39.16000
• Density: 1.225 g/cm³
• LogP: 2.59620
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 133.052763847
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzofuran-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C2C=COC2=C1)N

Technology Process of Benzofuran-4-amine

There total 8 articles about Benzofuran-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-nitro-benzofuran (69227-65-2) → 4-aminobenzofuran (412336-07-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 1520 Torr;

DOI:10.1039/P29840001479

Reference yield: 50.0%

N-benzofuran-4-yl-2-hydroxy-2-methyl-propionamide (909398-10-3) → 4-aminobenzofuran (412336-07-3)

Guidance literature:

With hydrogenchloride; for 2h;

DOI:10.1080/00397910600634118

Reference yield:

methyl 3-hydroxybenzoate (19438-10-9) + allyl bromide (106-95-6) → methyl 3-(prop-2-enyloxy)benzoate (79250-46-7) + 4-aminobenzofuran (412336-07-3)

Guidance literature:

With sodium iodide; potassium carbonate; In acetone;

upstream raw materials:

4-nitro-benzofuran

tert-butyl (1-benzofuran-4-yl)carbamate

N-benzofuran-4-yl-2-hydroxy-2-methyl-propionamide

2-(benzofuran-4-yloxy)-2-methyl-propionamide

Downstream raw materials:

benzofuran-4-carbonitrile

4-acetylbenzofuran

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