79250-46-7

Basic information

• Product Name: Methyl 3-(allyloxy)benzoate
• Synonyms: Methyl 3-(allyloxy)benzoate;Benzoic acid, 3-(2-propen-1-yloxy)-, methyl ester
• CAS NO: 79250-46-7
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21118
• Mol File: 79250-46-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 3-(allyloxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-(allyloxy)benzoate(79250-46-7)
• EPA Substance Registry System: Methyl 3-(allyloxy)benzoate(79250-46-7)

Safety Data

• Hazardous Substances Data: 79250-46-7(Hazardous Substances Data)

Upstream product

• 1458-98-6 2-methyl-3-bromo-1-propene 
• 19438-10-9 methyl 3-hydroxybenzoate 
• 67-56-1 methanol 
• 103203-83-4 3-(allyloxy)benzoic acid 
• 99-06-9 3-Carboxyphenol 
• 107-05-1 3-chloroprop-1-ene 
• 106-95-6 allyl bromide 
• 185112-19-0 (R)-(3-Allyloxy-phenyl)-azido-acetic acid 
• 185112-18-9 (2R,4R)-3-<2-azido-2-<3-(allyloxy)phenyl>-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone 
• 186581-53-3 diazomethane 

Downstream Products

• 67032-33-1 methyl (±)-3-(2,3-dihydroxypropoxy)benzoate 
• 1189173-32-7 1,1,1,3,3,3-hexafluoro-2-(2-(hydroxymethyl)-4-(methoxymethoxy)-3-n-propyl-phenyl)propan-2-ol 
• 1189173-31-6 1,1,1,3,3,3-hexafluoro-2-(4-(methoxymethoxy)-3-n-propyl-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)propan-2-ol 
• 1189173-30-5 2-((6-bromo-3-(methoxymethoxy)-2-n-propylbenzyl)oxy)tetrahydro-2H-pyran 
• 1189173-29-2 4-bromo-2-n-propyl-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenol 
• 1189173-28-1 4-bromo-3-(hydroxymethyl)-2-n-propylphenol 
• 1189173-27-0 3-hydroxymethyl-2-n-propylphenol 
• 79950-41-7 methyl 3-hydroxy-4-(2-propenyl)benzoate 
• 79950-39-3 2-allyl-3-hydroxy-benzoic acid methyl ester 

Relevant articles and documents

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface

Autophagy is the common name for a number of lysosome-based degradation pathways of cytosolic cargos. The key components of autophagy are members of Atg8 family proteins involved in almost all steps of the process, from autophagosome formation to their selective fusion with lysosomes. In this study, we show that the homologous members of the human Atg8 family proteins, LC3A and LC3B, are druggable by a small molecule inhibitor novobiocin. Structure-activity relationship (SAR) studies of the 4-hydroxy coumarin core scaffold were performed, supported by a crystal structure of the LC3A dihydronovobiocin complex. The study reports the first nonpeptide inhibitors for these protein interaction targets and will lay the foundation for the development of more potent chemical probes for the Atg8 protein family which may also find applications for the development of autophagy-mediated degraders (AUTACs).

The curved front row neil intermediate preparation method

The invention relates to a preparation method for a treprostinil intermediate (I). The preparation method comprises the steps that: a compound of a formula (II) and a compound of a formula (III) or acidic salt thereof react in the presence of a condensing agent to obtain a compound of a formula (IV); the compound of the formula (IV) and a compound of a formula (V) react to obtain a compound of a formula (I). According to the preparation method for the treprostinil intermediate, weinreb amide and alkyne negative ions react to directly obtain a ketone compound (I), so that environment pollution caused by heavy metal (a PCC oxidant) is avoided, and the adoption of a butyl lithium low-temperature reaction method is also avoided. The preparation method for the treprostinil intermediate has the advantages that reaction conditions are mild, the yield is high, the purity of products is high, and the industrial application prospect is wide. (Formulae (I), (II), (III), (IV) and (V) are shown in the specification)

Nano-dispersed platinum(0) in organically modified silicate matrices as sustainable catalysts for a regioselective hydrosilylation of alkenes and alkynes

Nano-dispersed platinum(0) particles stabilized in a range of organically modified silicate (ORMOSIL) matrices are investigated as sustainable catalysts for the hydrosilylation of alkenes and alkynes. In this study, five different siloxane matrices including triethoxysilane (HTEOS), methyltriethoxysilane (MTES), ethyltriethoxysilane (ETES), triethoxyvinylsilane (TEVS) and propyltriethoxysilane (PTES) are investigated, and the distribution of the metal particles in these materials analyzed by transition electron microscopy (TEM). The particles appeared to be generally of a small size, with a diameter of ca. 2-5 nm in each of these catalysts, however the distribution is not equally uniform from one matrix to the other. HTEOS, MTES and ETES that respectively carry a hydrogen, a methyl and an ethyl group on the triethoxysilane moiety, displayed a more uniform distribution, while particles appeared to be more scattered in the remaining matrices. Catalysts with a uniform particles distribution produced higher and consistent yields, while those with poor particles distribution produced lower and almost random yields, suggesting that the uniformity in particle distribution, and by extension the nature of the siloxane matrix, are important for the catalytic properties of these materials. The scope of the reaction was broadened to a range of olefins, with a goal of investigating the tolerability of the reaction toward a number of reactive functional groups, resulting in the preparation of 28 compounds. This catalytic system also enabled the hydrosilylation of a limited number of alkynes under the optimized reaction conditions.