4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 138022-02-3
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.335
• Hs Code.: 29333990
• Mol file: 138022-02-3.mol

Synonyms:tert-Butyl 4-[(methylamino)methyl]piperidine-1-carboxylate;

Chemical Property of 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.469
• Boiling Point: 300.981 °C at 760 mmHg
• PKA: 10.41±0.10(Predicted)
• Flash Point: 135.829 °C
• PSA: 41.57000
• Density: 0.988 g/cm³
• LogP: 2.18170
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

tert-butyl4-((methylamino)methyl)piperidine-1-carboxylate 95-98% ^*data from reagent suppliers

Safty Information:

• Statements: 36737/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 2 articles about 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

tert-butyl 4-(methylcarbamoyl)piperidine-1-carboxylate (544696-01-7) → 4-[(methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester (138022-02-3)

Guidance literature:

tert-butyl 4-(methylcarbamoyl)piperidine-1-carboxylate; With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 0.5h;

With iodine; In tetrahydrofuran; for 18h; Heating / reflux;

With sodium hydroxide; In water;

Reference yield:

N-methyl-N-(1-tert-butoxycarbonylpiperidin-4-ylmethyl)trifluoroacetamide → 4-[(methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester (138022-02-3)

Guidance literature:

With sodium borohydrid; sodium chloride; In ethanol; dichloromethane; water;

Reference yield: 89.0%

4-[(methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester (138022-02-3) + 4-cyanobenzoic Acid (619-65-8,333406-09-0) → 4-{[(4-cyanobenzoyl)methylamino]methyl}piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:

4-cyanobenzoic Acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

4-[(methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

tert-butyl 4-(methylcarbamoyl)piperidine-1-carboxylate

Downstream raw materials:

methyl-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-piperidin-4-ylmethyl-amine

methyl-{1-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-piperidin-4-ylmethyl}-amine

C₂₄H₃₂N₈S

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