544696-01-7

Basic information

• Product Name: 1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXYLIC ACIDMETHYL AMIDE
• Synonyms: 1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXYLIC ACIDMETHYL AMIDE
• CAS NO: 544696-01-7
• Molecular Formula: C12H22N2O3
• Molecular Weight: 242.31
• Mol File: 544696-01-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 98-100°C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXYLIC ACIDMETHYL AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXYLIC ACIDMETHYL AMIDE(544696-01-7)
• EPA Substance Registry System: 1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXYLIC ACIDMETHYL AMIDE(544696-01-7)

Safety Data

• Hazardous Substances Data: 544696-01-7(Hazardous Substances Data)

Usage

General Description

1-Tert-butoxycarbonylpiperidine-4-carboxylic acid methyl amide is a chemical compound with the molecular formula C14H24N2O4. It is a derivative of piperidine and is commonly used in organic synthesis as a protecting group for amines. 1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXYLIC ACIDMETHYL AMIDE is characterized by its tert-butoxy carbonyl (Boc) group, which acts as a protective agent for the piperidine ring. It is often used in the preparation of various pharmaceutical and medicinal compounds, as well as in the study of organic chemistry reactions involving piperidine derivatives. 1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXYLIC ACIDMETHYL AMIDE's unique structure and reactivity make it an important building block in the synthesis of complex molecules and pharmaceuticals.

Upstream product

• 593-51-1 methylamine hydrochloride 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 74-89-5 methylamine 

Downstream Products

• 1903-69-1 piperidine-4-carboxylic acid methylamide 
• 138022-02-3 4-[(methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

SULFONAMIDE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT OF CANCER

The present disclosure relates generally to a class of sulfonamide-based compounds, compositions containing the same and the therapeutic use of the compounds in the treatment of cancer.

Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen

WNT signaling is frequently deregulated in malignancy, particularly in colon cancer, and plays a key role in the generation and maintenance of cancer stem cells. We report the discovery and optimization of a 3,4,5-trisubstituted pyridine 9 using a high-throughput cell-based reporter assay of WNT pathway activity. We demonstrate a twisted conformation about the pyridine-piperidine bond of 9 by small-molecule X-ray crystallography. Medicinal chemistry optimization to maintain this twisted conformation, cognisant of physicochemical properties likely to maintain good cell permeability, led to 74 (CCT251545), a potent small-molecule inhibitor of WNT signaling with good oral pharmacokinetics. We demonstrate inhibition of WNT pathway activity in a solid human tumor xenograft model with evidence for tumor growth inhibition following oral dosing. This work provides a successful example of hypothesis-driven medicinal chemistry optimization from a singleton hit against a cell-based pathway assay without knowledge of the biochemical target.

PYRIDINE AND PYRIMIDINE BASED COMPOUNDS AS WNT SIGNALING PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER

The present invention relates to pyridine and pyrimidine based compounds, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and / or prevention of cancer.