1-Boc-(4-benzyl)piperazine

Base Information

• Chemical Name: 1-Boc-(4-benzyl)piperazine
• CAS No.: 57260-70-5
• Molecular Formula: C16H24N2O2
• Molecular Weight: 276.379
• Hs Code.: 2933599090

Synonyms:1-(tert-Butoxycarbonyl)-4-(phenylmethyl)piperazine;1-(tert-Butyloxycarbonyl)-4-benzylpiperazine;4-Benzylpiperazine-1-carboxylicacid tert-butyl ester;tert-Butyl 4-benzyl-1-piperazinecarboxylate;

Chemical Property of 1-Boc-(4-benzyl)piperazine

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 1.92E-05mmHg at 25°C
• Melting Point: 71-73 ºC
• Refractive Index: 1.538
• Boiling Point: 362.5 °C at 760 mmHg
• PKA: 6.50±0.10(Predicted)
• Flash Point: 173.1 °C
• PSA: 32.78000
• Density: 1.087 g/cm³
• LogP: 2.61510
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl4-Benzylpiperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-(4-benzyl)piperazine

There total 22 articles about 1-Boc-(4-benzyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-phenylmethylpiperazine (2759-28-6) + di-tert-butyl dicarbonate (24424-99-5) → 4-benzyl-piperazine-1-carboxylic acid tert-butyl ester (57260-70-5)

Guidance literature:

In methanol; at 20 ℃;

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + N-benzyl-piperazine hydrochloride (110475-31-5) → 4-benzyl-piperazine-1-carboxylic acid tert-butyl ester (57260-70-5)

Guidance literature:

With dmap; TEA; In dichloromethane; for 0.25h;

DOI:10.1124/jpet.107.135103

Reference yield: 98.0%

4-benzoylpiperazine-1-carboxylic acid tert-butyl ester (77278-38-7) → 4-benzyl-piperazine-1-carboxylic acid tert-butyl ester (57260-70-5)

Guidance literature:

With diethylzinc; lithium chloride; In tetrahydrofuran; hexane; at 20 ℃; for 24h; chemoselective reaction; Catalytic behavior; Inert atmosphere;

DOI:10.1021/ol503430t

upstream raw materials:

benzyl chloride

1-t-Butoxycarbonylpiperazine

1-phenylmethylpiperazine

di-tert-butyl dicarbonate

Downstream raw materials:

1-phenylmethylpiperazine

1-tert-Butoxycarbonyl-2(S)-(S),4-dibenzylpiperazine

N-benzyl-piperazine hydrochloride

7-benzyl-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]-piperazin-3-one

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