2-(3,5-dimethylisoxazol-4-yl)-N-ethyl-3-(4-methoxyphenyl)-1H-indole-1-carboxamide

Base Information

Chemical Name:2-(3,5-dimethylisoxazol-4-yl)-N-ethyl-3-(4-methoxyphenyl)-1H-indole-1-carboxamide
CAS No.:1288963-75-6
Molecular Formula:C₂₃H₂₃N₃O₃
Molecular Weight:389.454
Hs Code.:

Synonyms:2-(3,5-dimethylisoxazol-4-yl)-N-ethyl-3-(4-methoxyphenyl)-1H-indole-1-carboxamide

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Chemical Property of 2-(3,5-dimethylisoxazol-4-yl)-N-ethyl-3-(4-methoxyphenyl)-1H-indole-1-carboxamide

Chemical Property:

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Technology Process of 2-(3,5-dimethylisoxazol-4-yl)-N-ethyl-3-(4-methoxyphenyl)-1H-indole-1-carboxamide

There total 6 articles about 2-(3,5-dimethylisoxazol-4-yl)-N-ethyl-3-(4-methoxyphenyl)-1H-indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1288963-67-6
4-(3-(4-methoxyphenyl)-1H-indol-2-yl)-3,5-dimethylisoxazole

: 109-90-0
ethyl isocyanate

: 1288963-75-6
2-(3,5-dimethylisoxazol-4-yl)-N-ethyl-3-(4-methoxyphenyl)-1H-indole-1-carboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 70 ℃; Inert atmosphere;

Reference yield:

: 99655-68-2
3-bromo-1-phenylsulfonyl indole

: 1288963-75-6
2-(3,5-dimethylisoxazol-4-yl)-N-ethyl-3-(4-methoxyphenyl)-1H-indole-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 85 °C / Inert atmosphere

2: potassium carbonate; methanol / 16 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide / dichloromethane / 0.03 h

4: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.75 h / 90 °C / Inert atmosphere

5: N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With methanol; N-Bromosuccinimide; sodium hydrogencarbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1288963-75-6
2-(3,5-dimethylisoxazol-4-yl)-N-ethyl-3-(4-methoxyphenyl)-1H-indole-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 85 °C / Inert atmosphere

2: potassium carbonate; methanol / 16 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide / dichloromethane / 0.03 h

4: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.75 h / 90 °C / Inert atmosphere

5: N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With methanol; N-Bromosuccinimide; sodium hydrogencarbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;