(S)-3-[N-(tert-Butoxycarbonyl)-N-phenylethylamino]-2-oxo-1-piperidineacetic acid, benzyl ester

Base Information

Chemical Name:(S)-3-[N-(tert-Butoxycarbonyl)-N-phenylethylamino]-2-oxo-1-piperidineacetic acid, benzyl ester
CAS No.:174961-47-8
Molecular Formula:C₂₇H₃₄N₂O₅
Molecular Weight:466.577
Hs Code.:

Synonyms:(S)-3-[N-(tert-Butoxycarbonyl)-N-phenylethylamino]-2-oxo-1-piperidineacetic acid, benzyl ester

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Chemical Property of (S)-3-[N-(tert-Butoxycarbonyl)-N-phenylethylamino]-2-oxo-1-piperidineacetic acid, benzyl ester

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Technology Process of (S)-3-[N-(tert-Butoxycarbonyl)-N-phenylethylamino]-2-oxo-1-piperidineacetic acid, benzyl ester

There total 7 articles about (S)-3-[N-(tert-Butoxycarbonyl)-N-phenylethylamino]-2-oxo-1-piperidineacetic acid, benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 174961-47-8
(S)-3-[N-(tert-Butoxycarbonyl)-N-phenylethylamino]-2-oxo-1-piperidineacetic acid, benzyl ester

Guidance literature:

Reference yield:

: 122-78-1
phenylacetaldehyde

: 174961-47-8
(S)-3-[N-(tert-Butoxycarbonyl)-N-phenylethylamino]-2-oxo-1-piperidineacetic acid, benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / Na(OAc)3BH, Et₃N, DCE / Ambient temperature

2: NaHCO₃ / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

With DCE; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; water;
DOI:10.1016/S0960-894X(98)00636-2

Reference yield:

: 100-39-0
benzyl bromide

: 174961-47-8
(S)-3-[N-(tert-Butoxycarbonyl)-N-phenylethylamino]-2-oxo-1-piperidineacetic acid, benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / K₂CO₃ / dimethylformamide; acetonitrile / Heating

2: 100 percent / 5 N aq. HCl / ethyl acetate / 3 h / Ambient temperature

3: 66 percent / Na(OAc)3BH, Et₃N, DCE / Ambient temperature

4: NaHCO₃ / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

With hydrogenchloride; DCE; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(98)00636-2