5-(10-fluoro-6-oxo-5, 6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(10-fluoro-6-oxo-5, 6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1621886-95-0
Molecular Formula:C₃₂H₂₃F₂N₅O₅S
Molecular Weight:627.628
Hs Code.:

5-(10-fluoro-6-oxo-5, 6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Synonyms:5-(10-fluoro-6-oxo-5, 6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(10-fluoro-6-oxo-5, 6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(10-fluoro-6-oxo-5, 6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 3 articles about 5-(10-fluoro-6-oxo-5, 6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1621888-60-5
2-chloro-10-fluoropyrido[3',2':4,5]pyrimido [1,6-a]indol-6(5H)-one

: 1621886-95-0
5-(10-fluoro-6-oxo-5, 6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate; XPhos; In 1,4-dioxane; water; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 129822-47-5
tert‐butyl 5‐fluoroindole‐1‐carboxylate

: 1621886-95-0
5-(10-fluoro-6-oxo-5, 6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 0.67 h / -78 °C

2.1: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / 1,4-dioxane / 70 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium phosphate tribasic trihydrate / water; 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; potassium phosphate tribasic trihydrate; caesium carbonate; lithium diisopropyl amide; XPhos; In tetrahydrofuran; 1,4-dioxane; water; 2.1: |Suzuki Coupling / 3.1: |Suzuki Coupling;

Reference yield:

: 352359-23-0
[1-(tert-butoxycarbonyl)-5-fluoro-1H-indol-2-yl]boronic acid

: 1621886-95-0
5-(10-fluoro-6-oxo-5, 6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / 1,4-dioxane / 70 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium phosphate tribasic trihydrate / water; 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; potassium phosphate tribasic trihydrate; caesium carbonate; XPhos; In 1,4-dioxane; water; 1: |Suzuki Coupling / 2: |Suzuki Coupling;