4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carboxylic acid methyl ester

Base Information

• Chemical Name: 4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carboxylic acid methyl ester
• CAS No.: 185540-74-3
• Molecular Formula: C₁₇H₁₇NO₄S₂
• Molecular Weight: 363.458
• Mol file: 185540-74-3.mol

Synonyms:4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carboxylic acid methyl ester

Chemical Property of 4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carboxylic acid methyl ester

There total 5 articles about 4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-(2-Chloro-ethylsulfanyl)-4-(toluene-4-sulfonylamino)-benzoic acid methyl ester (185540-73-2) → 4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carboxylic acid methyl ester (185540-74-3)

Guidance literature:

With sodium hydride; In toluene; at 100 ℃; for 2h;

DOI:10.1021/jm9605288

Reference yield:

4-amino-3-mercaptobenzoic acid hydrochloride (1571-66-0) → 4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carboxylic acid methyl ester (185540-74-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / NaOH / ethanol; H₂O / 3.5 h / Ambient temperature

2: 78 percent / HCl (gas) / Ambient temperature

3: 87 percent / pyridine / 5 h / 60 °C

4: 68 percent / NaH / toluene / 2 h / 100 °C

With pyridine; hydrogenchloride; sodium hydroxide; sodium hydride; In ethanol; water; toluene;

DOI:10.1021/jm9605288

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carboxylic acid methyl ester (185540-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine / 5 h / 60 °C

2: 68 percent / NaH / toluene / 2 h / 100 °C

With pyridine; sodium hydride; In toluene;

DOI:10.1021/jm9605288

upstream raw materials:

3-(2-Chloro-ethylsulfanyl)-4-(toluene-4-sulfonylamino)-benzoic acid methyl ester

4-amino-3-mercaptobenzoic acid hydrochloride

p-toluenesulfonyl chloride

4-Amino-3-(2-chloro-ethylsulfanyl)-benzoic acid

Downstream raw materials:

4-tosyl-3,4-dihydro-2H-benzo[b][1,4]-thiazine-7-carboxylic acid

4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carbonyl chloride

(S)-2-{[4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carbonyl]-amino}-hexanedioic acid dimethyl ester

(S)-2-{[4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]thiazine-7-carbonyl]-amino}-pentanedioic acid diethyl ester