5-tert-butoxycarbonylamino-3'-[(5-tert-butoxycarbonylamino-3'-nitrobiphenyl-3-carbonyl)amino]biphenyl-3-carboxylic acid 2-trimethylsilanylethyl ester

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Chemical Name:5-tert-butoxycarbonylamino-3'-[(5-tert-butoxycarbonylamino-3'-nitrobiphenyl-3-carbonyl)amino]biphenyl-3-carboxylic acid 2-trimethylsilanylethyl ester
CAS No.:337973-09-8
Molecular Formula:C₄₁H₄₈N₄O₉Si
Molecular Weight:768.939
Hs Code.:

5-tert-butoxycarbonylamino-3'-[(5-tert-butoxycarbonylamino-3'-nitrobiphenyl-3-carbonyl)amino]biphenyl-3-carboxylic acid 2-trimethylsilanylethyl ester

Synonyms:5-tert-butoxycarbonylamino-3'-[(5-tert-butoxycarbonylamino-3'-nitrobiphenyl-3-carbonyl)amino]biphenyl-3-carboxylic acid 2-trimethylsilanylethyl ester

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Chemical Property of 5-tert-butoxycarbonylamino-3'-[(5-tert-butoxycarbonylamino-3'-nitrobiphenyl-3-carbonyl)amino]biphenyl-3-carboxylic acid 2-trimethylsilanylethyl ester

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Technology Process of 5-tert-butoxycarbonylamino-3'-[(5-tert-butoxycarbonylamino-3'-nitrobiphenyl-3-carbonyl)amino]biphenyl-3-carboxylic acid 2-trimethylsilanylethyl ester

There total 6 articles about 5-tert-butoxycarbonylamino-3'-[(5-tert-butoxycarbonylamino-3'-nitrobiphenyl-3-carbonyl)amino]biphenyl-3-carboxylic acid 2-trimethylsilanylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6313-17-3
3-iodo-5-nitro-benzoic acid

: 337973-09-8
5-tert-butoxycarbonylamino-3'-[(5-tert-butoxycarbonylamino-3'-nitrobiphenyl-3-carbonyl)amino]biphenyl-3-carboxylic acid 2-trimethylsilanylethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / (NH₄)2Fe(SO₄)2; aq. NH₃ / 0.17 h / Heating

2: 1.04 g / dioxane; aq. KOH

3: 83 percent / aq. Na₂CO₃; Pd(OAc)2 / dimethylformamide / 4 h / 80 °C

4: DMAP; DCC / CH₂Cl₂; tetrahydrofuran

5: H₂ / Pd/C / methanol; ethyl acetate / 2068.59 Torr

6: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

With dmap; palladium diacetate; ammonium iron (II) sulfate; ammonium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; potassium hydroxide; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3: Suzuki coupling;
DOI:10.1021/ja034563x

Reference yield:

: 337973-06-5
3-[(tert-butoxycarbonyl)amino]-5-iodobenzoic acid

: 337973-09-8
5-tert-butoxycarbonylamino-3'-[(5-tert-butoxycarbonylamino-3'-nitrobiphenyl-3-carbonyl)amino]biphenyl-3-carboxylic acid 2-trimethylsilanylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / aq. Na₂CO₃; Pd(OAc)2 / dimethylformamide / 4 h / 80 °C

2: DMAP; DCC / CH₂Cl₂; tetrahydrofuran

3: H₂ / Pd/C / methanol; ethyl acetate / 2068.59 Torr

4: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

With dmap; palladium diacetate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/ja034563x

Reference yield:

: 102153-73-1
3-amino-5-iodobenzoic acid

: 337973-09-8
5-tert-butoxycarbonylamino-3'-[(5-tert-butoxycarbonylamino-3'-nitrobiphenyl-3-carbonyl)amino]biphenyl-3-carboxylic acid 2-trimethylsilanylethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.04 g / dioxane; aq. KOH

2: 83 percent / aq. Na₂CO₃; Pd(OAc)2 / dimethylformamide / 4 h / 80 °C

3: DMAP; DCC / CH₂Cl₂; tetrahydrofuran

4: H₂ / Pd/C / methanol; ethyl acetate / 2068.59 Torr

5: bis(2-oxo-3-oxazolidinyl)phosphinic chloride; DIEA / tetrahydrofuran

With dmap; palladium diacetate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; potassium hydroxide; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/ja034563x