6313-17-3

Usage

Uses

Used in Organic Synthesis:
3-IODO-5-NITROBENZOIC ACID is used as a versatile building block for the synthesis of heterocyclic compounds and various pharmaceutical intermediates. Its unique structure allows for the creation of a diverse range of chemical products, making it an essential component in the field of organic chemistry.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-IODO-5-NITROBENZOIC ACID is used as a key intermediate in the development of new drugs. Its potential antibacterial and anti-inflammatory properties are currently being studied, which could lead to the discovery of novel therapeutic agents for treating various medical conditions.
Used in Medicinal Research and Drug Development:
3-IODO-5-NITROBENZOIC ACID is also valuable in medicinal research and drug development due to its potential applications in creating new pharmaceutical compounds. Researchers are exploring its properties to understand its full potential and to develop innovative treatments for a range of diseases and disorders.

InChI:InChI=1/C7H4INO4/c8-5-1-4(7(10)11)2-6(3-5)9(12)13/h1-3H,(H,10,11)

Upstream product

• 618-84-8 3-amino-5-nitro-benzoic acid 
• 121-92-6 3-nitrobenzoic acid 
• 610-29-7 2-nitroterephthalic acid 

Downstream Products

• 50765-19-0 methyl 3-iodo-5-nitrobenzoate 
• 145028-74-6 2-Bromo-1-(3-iodo-5-nitro-phenyl)-ethanone 
• 145028-78-0 2-(2-Imino-thiazolidin-3-yl)-1-(3-iodo-5-nitro-phenyl)-ethanol 
• 145028-83-7 3-[2-Chloro-2-(3-iodo-5-nitro-phenyl)-ethyl]-thiazolidin-2-ylideneamine 
• 145028-63-3 4-Chloro-N-[3-iodo-5-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-benzamide 
• 145235-68-3 6-(3-amino-5-iodophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride 
• 145235-77-4 6-(3-Iodo-5-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole; hydrochloride 
• 145235-73-0 2-(2-Imino-thiazolidin-3-yl)-1-(3-iodo-5-nitro-phenyl)-ethanone; hydrobromide 
• 19094-48-5 3,5-diiodobenzoic acid 
• 1138322-95-8 2'-methoxy-5-nitro-biphenyl-3-carboxylic acid 
• 50765-26-9 3-Benzyloxy-5-iodbenzylcyanid 
• 50765-22-5 methyl 3-hydroxy-5-iodobenzoate 
• 217314-45-9 methyl 3-amino-5-iodobenzoate 
• 50765-28-1 2-(3-Hydroxy-5-iodphenyl)aethylamin 

Relevant academic research and scientific papers

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

Method for synthesizing m-iodonitrobenzene compound

Provided is a method for synthesizing m-iodonitrobenzene; in the presence of oxygen gas, a palladium catalyst, a copper additive, a bismuth reagent and potassium phosphate, an o-nitrobenzoic acid compound and metal iodide are subjected to a substitution reaction in an organic solvent to form a corresponding m-iodonitrobenzene compound, wherein a metal in the metal iodide is an alkali metal or an alkaline earth metal. The method has obvious advantages of cheap and easily obtained reaction raw materials (including o-nitrobenzoic acid and MI), small amount of the metal catalyst, minimum environmental pollution with oxygen gas as an oxidant, good tolerance on various functional groups on an aromatic ring and the like. The method can be widely applied in the fields of synthesis of drugs, materials, natural products and the like in industrial and academic circles.

TETRAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is a group of formula A or formula B, and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.

THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted thiadiazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula 1: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted phenyl or optionally substituted pyridinyl, and R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5, R6 R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists

Compounds of the formula I: wherein R1 is optionally substituted imidazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.

Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted pyrazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.