Technology Process of 2,2-diethoxy-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)acetamide
There total 5 articles about 2,2-diethoxy-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane;
at 120 ℃;
for 4h;
Inert atmosphere;
DOI:10.1002/ejoc.201200168
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ethyl acetate / Acidic conditions
2.1: triethylamine / butan-1-ol / 5 h / 60 °C
3.1: diisopropylamine; lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
4.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4 h / 120 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; ethyl acetate; triethylamine; diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; butan-1-ol;
DOI:10.1002/ejoc.201200168
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diisopropylamine; lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 4 h / 120 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; diisopropylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane;
DOI:10.1002/ejoc.201200168