(E)-3-(4,5-dimethoxy-2-methoxycarbonylmethylphenyl)but-2-enoic acid methyl ester

Base Information

Chemical Name:(E)-3-(4,5-dimethoxy-2-methoxycarbonylmethylphenyl)but-2-enoic acid methyl ester
CAS No.:1315171-91-5
Molecular Formula:C₁₆H₂₀O₆
Molecular Weight:308.331
Hs Code.:

Synonyms:(E)-3-(4,5-dimethoxy-2-methoxycarbonylmethylphenyl)but-2-enoic acid methyl ester

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Chemical Property of (E)-3-(4,5-dimethoxy-2-methoxycarbonylmethylphenyl)but-2-enoic acid methyl ester

Chemical Property:

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Technology Process of (E)-3-(4,5-dimethoxy-2-methoxycarbonylmethylphenyl)but-2-enoic acid methyl ester

There total 3 articles about (E)-3-(4,5-dimethoxy-2-methoxycarbonylmethylphenyl)but-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 623-43-8
crotonic acid methyl ester

: 35345-49-4
2-iodo-4,5-dimethoxyphenylacetic acid methyl ester

: 1315171-91-5
(E)-3-(4,5-dimethoxy-2-methoxycarbonylmethylphenyl)but-2-enoic acid methyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In acetonitrile; for 96h; Inert atmosphere; Reflux;
DOI:10.1021/jm200334c

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 1315171-91-5
(E)-3-(4,5-dimethoxy-2-methoxycarbonylmethylphenyl)but-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Iodine monochloride; acetic acid / dichloromethane / Inert atmosphere

2: Amberlyst / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 96 h / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; Iodine monochloride; acetic acid; triethylamine; In dichloromethane; acetonitrile; 3: Heck reaction;
DOI:10.1021/jm200334c

Reference yield:

: 35323-09-2
(2-iodo-4,5-dimethoxyphenyl)acetic acid

: 1315171-91-5
(E)-3-(4,5-dimethoxy-2-methoxycarbonylmethylphenyl)but-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Amberlyst / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 96 h / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In acetonitrile; 2: Heck reaction;
DOI:10.1021/jm200334c