[2-((3aR,5R,6R,6aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-phosphonic acid dibenzyl ester

Base Information

Chemical Name:[2-((3aR,5R,6R,6aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-phosphonic acid dibenzyl ester
CAS No.:669015-55-8
Molecular Formula:C₂₃H₂₉O₇P
Molecular Weight:448.453
Hs Code.:

Synonyms:[2-((3aR,5R,6R,6aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-phosphonic acid dibenzyl ester

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Chemical Property of [2-((3aR,5R,6R,6aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-phosphonic acid dibenzyl ester

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Technology Process of [2-((3aR,5R,6R,6aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-phosphonic acid dibenzyl ester

There total 7 articles about [2-((3aR,5R,6R,6aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-phosphonic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1,2-O-isopropylidene-3-O-t-butyldimethylsilyl-5,6-deoxy-6-dibenzylphosphono-α-D-allofuranose

: 669015-55-8
[2-((3aR,5R,6R,6aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-phosphonic acid dibenzyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.tetlet.2003.11.001

Reference yield:

: 23202-83-7,2592-42-9
5-benzyl-1,2-O-isopropylidene-α-D-xylofuranose

: 669015-55-8
[2-((3aR,5R,6R,6aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-phosphonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: (COCl)2; DMSO; TEA

2: NaBH₄ / methanol / 0 °C

3: 90 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

4: 98 percent / H₂ / Pd/C / ethyl acetate / 144 h

5: TEA / CCl₄ / -40 °C

6: n-BuLi; HMPA / tetrahydrofuran / -78 °C

7: TBAF / tetrahydrofuran / 20 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; TEA; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; ethyl acetate; 1: Swern oxidation;
DOI:10.1016/j.tetlet.2003.11.001

Reference yield:

: 34311-63-2
5-O-benzyl-3-oxo-1,2-O-isopropylidene-α-D-xylofuranose

: 669015-55-8
[2-((3aR,5R,6R,6aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-phosphonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaBH₄ / methanol / 0 °C

2: 90 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

3: 98 percent / H₂ / Pd/C / ethyl acetate / 144 h

4: TEA / CCl₄ / -40 °C

5: n-BuLi; HMPA / tetrahydrofuran / -78 °C

6: TBAF / tetrahydrofuran / 20 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; n-butyllithium; TEA; tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2003.11.001