C₂₁H₂₈FNO₅

Base Information

Chemical Name:C₂₁H₂₈FNO₅
CAS No.:1356352-04-9
Molecular Formula:C₂₁H₂₈FNO₅
Molecular Weight:393.455
Hs Code.:

C<sub>21</sub>H<sub>28</sub>FNO<sub>5</sub>

Synonyms:C₂₁H₂₈FNO₅

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Chemical Property of C₂₁H₂₈FNO₅

Chemical Property:

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Technology Process of C₂₁H₂₈FNO₅

There total 4 articles about C₂₁H₂₈FNO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 91229-91-3
tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate

: 459-46-1
4-Fluorobenzyl bromide

: 1356352-04-9
C₂₁H₂₈FNO₅

Guidance literature:: tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

4-Fluorobenzyl bromide; In tetrahydrofuran; at -78 ℃; for 2.1666h; Inert atmosphere;
DOI:10.1021/jm201533b

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 1356352-04-9
C₂₁H₂₈FNO₅

Guidance literature:: Multi-step reaction with 3 steps

1.1: perchloric acid / water / 18 h / 20 °C

2.1: dmap / acetonitrile / 48.58 h / 0 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

3.2: 2.17 h / -78 °C / Inert atmosphere

With dmap; perchloric acid; lithium hexamethyldisilazane; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm201533b

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1356352-04-9
C₂₁H₂₈FNO₅

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / acetonitrile / 48.58 h / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

2.2: 2.17 h / -78 °C / Inert atmosphere

With dmap; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm201533b