1-[1-(4-fluoro-benzenesulfonyl)-1H-indol-2-yl]-4,4-dimethoxy-cyclohexa-2,5-dienol

Base Information

• Chemical Name: 1-[1-(4-fluoro-benzenesulfonyl)-1H-indol-2-yl]-4,4-dimethoxy-cyclohexa-2,5-dienol
• CAS No.: 1026062-15-6
• Molecular Formula: C₂₂H₂₀FNO₅S
• Molecular Weight: 429.469

Synonyms:1-[1-(4-fluoro-benzenesulfonyl)-1H-indol-2-yl]-4,4-dimethoxy-cyclohexa-2,5-dienol

Chemical Property of 1-[1-(4-fluoro-benzenesulfonyl)-1H-indol-2-yl]-4,4-dimethoxy-cyclohexa-2,5-dienol

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Technology Process of 1-[1-(4-fluoro-benzenesulfonyl)-1H-indol-2-yl]-4,4-dimethoxy-cyclohexa-2,5-dienol

There total 3 articles about 1-[1-(4-fluoro-benzenesulfonyl)-1H-indol-2-yl]-4,4-dimethoxy-cyclohexa-2,5-dienol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4-dimethoxycyclohexa-2,5-dienone (935-50-2) + 1-((4-fluorophenyl)sulfonyl)-1H-indole (146384-55-6) → 1-[1-(4-fluoro-benzenesulfonyl)-1H-indol-2-yl]-4,4-dimethoxy-cyclohexa-2,5-dienol (1026062-15-6)

Guidance literature:

1-((4-fluorophenyl)sulfonyl)-1H-indole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

4,4-dimethoxycyclohexa-2,5-dienone; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

DOI:10.1021/jm040859h

Reference yield:

indole (120-72-9) → 1-[1-(4-fluoro-benzenesulfonyl)-1H-indol-2-yl]-4,4-dimethoxy-cyclohexa-2,5-dienol (1026062-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrabutylammonium hydrogen sulfate; aq. NaOH / toluene / 16 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -78 °C

2.2: tetrahydrofuran; hexane / 2 h / -78 °C

With sodium hydroxide; n-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; hexane; toluene;

DOI:10.1021/jm040859h

Reference yield:

4-Fluorobenzenesulfonyl chloride (349-88-2) → 1-[1-(4-fluoro-benzenesulfonyl)-1H-indol-2-yl]-4,4-dimethoxy-cyclohexa-2,5-dienol (1026062-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrabutylammonium hydrogen sulfate; aq. NaOH / toluene / 16 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -78 °C

2.2: tetrahydrofuran; hexane / 2 h / -78 °C

With sodium hydroxide; n-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; hexane; toluene;

DOI:10.1021/jm040859h

upstream raw materials:

4,4-dimethoxycyclohexa-2,5-dienone

1-((4-fluorophenyl)sulfonyl)-1H-indole

indole

4-Fluorobenzenesulfonyl chloride

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