2-O-Benzyl-1-O-octadecyl-sn-glycero-3-phosphorylcholin

Base Information

• Chemical Name: 2-O-Benzyl-1-O-octadecyl-sn-glycero-3-phosphorylcholin
• CAS No.: 80483-86-9
• Molecular Formula: C₃₃H₆₂NO₆P
• Molecular Weight: 599.832
• Mol file: 80483-86-9.mol

Synonyms:2-O-Benzyl-1-O-octadecyl-sn-glycero-3-phosphorylcholin

Chemical Property of 2-O-Benzyl-1-O-octadecyl-sn-glycero-3-phosphorylcholin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-O-Benzyl-1-O-octadecyl-sn-glycero-3-phosphorylcholin

There total 37 articles about 2-O-Benzyl-1-O-octadecyl-sn-glycero-3-phosphorylcholin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Cholin-p-toluolsulfonsaeureester + (S)-1-O-octadecyl-2-O-benzyl-glycerol (80707-93-3,89104-47-2) → 2-O-Benzyl-1-O-octadecyl-sn-glycero-3-phosphorylcholin (80483-86-9)

Guidance literature:

With pyridine; triethylamine; trichlorophosphate; In chloroform; Ambient temperature;

DOI:10.1002/hlca.19820650339

Reference yield:

(2R)-2-Benzyloxy-3-octadecyloxypropyl 2-bromoethyl phosphate (80459-32-1) → 2-O-Benzyl-1-O-octadecyl-sn-glycero-3-phosphorylcholin (80483-86-9)

Guidance literature:

silver carbonate; In methanol; trimethylamine-in-toluene;

Reference yield:

choline tosylate (55357-38-5) + (S)-1-O-octadecyl-2-O-benzyl-glycerol (80707-93-3,89104-47-2) → 2-O-Benzyl-1-O-octadecyl-sn-glycero-3-phosphorylcholin (80483-86-9)

Guidance literature:

(S)-1-O-octadecyl-2-O-benzyl-glycerol; With triethylamine; trichlorophosphate; In dichloromethane; for 0.5h;

choline tosylate; With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm049006f

upstream raw materials:

(S)-1-O-octadecyl-2-O-benzyl-glycerol

(2R)-2-Benzyloxy-3-octadecyloxypropyl 2-bromoethyl phosphate

trimethylamine

choline tosylate

Downstream raw materials:

Lyso-platelet-activating factor (C₁₈)

1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine

Refernces

• 1、 -. "Method of use of 1-(alkyl for alkylcarbanoyl)-2-carbamoylglycerol derivatives". . . Retrieved 2008/06/13.
• 2、 Hirth,Barner. "Synthesis of glyceryletherphosphatides, 1st communication. Preparation of 1-0-octadecyl-2-0-acetyl-sn-glyceryl-3-phosphorylcholine ('platelet activating factor'), of its enantiomer and of some analogous compounds". . p. 1059 - 1084. Retrieved 2007/10/02.