2-(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-ylmethylene)-malonic acid diethyl ester

Base Information

Chemical Name:2-(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-ylmethylene)-malonic acid diethyl ester
CAS No.:233765-83-8
Molecular Formula:C₁₈H₂₂FNO₄
Molecular Weight:335.375
Hs Code.:

2-(6-fluoro-2-methyl-3,4-dihydro-2<i>H</i>-quinolin-1-ylmethylene)-malonic acid diethyl ester

Synonyms:2-(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-ylmethylene)-malonic acid diethyl ester

Suppliers and Price of 2-(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-ylmethylene)-malonic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-ylmethylene)-malonic acid diethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-ylmethylene)-malonic acid diethyl ester

There total 1 articles about 2-(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-ylmethylene)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 199186-69-1
(R)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

: 233765-83-8
2-(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-ylmethylene)-malonic acid diethyl ester

Guidance literature:: at 125 ℃; for 2.5h;
DOI:10.1016/S0957-4166(99)00071-3

Reference yield:

: 233765-83-8
2-(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-ylmethylene)-malonic acid diethyl ester

: 215178-95-3,202349-45-9
R-(+)-flumequine

Guidance literature:: Multi-step reaction with 2 steps

1: 80.5 percent / polyphosphoric acid / toluene / 6 h / 110 °C

2: 75.4 percent / H₂O / 3 h / 100 °C

With PPA; water; In toluene;
DOI:10.1016/S0957-4166(99)00071-3