3-(4-fluorophenyl)-2-(prop-2-ynyloxy)-4-(pyridin-4-yl)quinoline

Base Information

• Chemical Name: 3-(4-fluorophenyl)-2-(prop-2-ynyloxy)-4-(pyridin-4-yl)quinoline
• CAS No.: 1019877-62-3
• Molecular Formula: C₂₃H₁₅FN₂O
• Molecular Weight: 354.383
• Mol file: 1019877-62-3.mol

Synonyms:3-(4-fluorophenyl)-2-(prop-2-ynyloxy)-4-(pyridin-4-yl)quinoline

Chemical Property of 3-(4-fluorophenyl)-2-(prop-2-ynyloxy)-4-(pyridin-4-yl)quinoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(4-fluorophenyl)-2-(prop-2-ynyloxy)-4-(pyridin-4-yl)quinoline

There total 1 articles about 3-(4-fluorophenyl)-2-(prop-2-ynyloxy)-4-(pyridin-4-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one (917460-80-1) + propargyl bromide (106-96-7) → 3-(4-fluorophenyl)-1-(prop-2-ynyl)-4-(pyridin-4-yl)quinolin-2(1H)-one (1019877-56-5) + 3-(4-fluorophenyl)-2-(prop-2-ynyloxy)-4-(pyridin-4-yl)quinoline (1019877-62-3)

Guidance literature:

3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one; With sodium hydride; In dimethyl sulfoxide; toluene; at 20 ℃; for 0.5h;

propargyl bromide; In dimethyl sulfoxide; toluene; for 1h; Further stages.;

DOI:10.1016/j.bmcl.2007.12.073

upstream raw materials:

3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one

propargyl bromide