3-(4-fluorophenyl)-1-(prop-2-ynyl)-4-(pyridin-4-yl)quinolin-2(1H)-one

Base Information

• Chemical Name: 3-(4-fluorophenyl)-1-(prop-2-ynyl)-4-(pyridin-4-yl)quinolin-2(1H)-one
• CAS No.: 1019877-56-5
• Molecular Formula: C₂₃H₁₅FN₂O
• Molecular Weight: 354.383
• Mol file: 1019877-56-5.mol

Synonyms:3-(4-fluorophenyl)-1-(prop-2-ynyl)-4-(pyridin-4-yl)quinolin-2(1H)-one

Chemical Property of 3-(4-fluorophenyl)-1-(prop-2-ynyl)-4-(pyridin-4-yl)quinolin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(4-fluorophenyl)-1-(prop-2-ynyl)-4-(pyridin-4-yl)quinolin-2(1H)-one

There total 1 articles about 3-(4-fluorophenyl)-1-(prop-2-ynyl)-4-(pyridin-4-yl)quinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one (917460-80-1) + propargyl bromide (106-96-7) → 3-(4-fluorophenyl)-1-(prop-2-ynyl)-4-(pyridin-4-yl)quinolin-2(1H)-one (1019877-56-5) + 3-(4-fluorophenyl)-2-(prop-2-ynyloxy)-4-(pyridin-4-yl)quinoline (1019877-62-3)

Guidance literature:

3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one; With sodium hydride; In dimethyl sulfoxide; toluene; at 20 ℃; for 0.5h;

propargyl bromide; In dimethyl sulfoxide; toluene; for 1h; Further stages.;

DOI:10.1016/j.bmcl.2007.12.073

upstream raw materials:

3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one

propargyl bromide