ethyl 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

Base Information

Chemical Name:ethyl 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate
CAS No.:1449428-71-0
Molecular Formula:C₂₈H₂₆Cl₂N₄O₆S₂
Molecular Weight:649.576
Hs Code.:

Synonyms:ethyl 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

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Chemical Property of ethyl 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

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Technology Process of ethyl 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

There total 7 articles about ethyl 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,4-dichloro-5-(morpholinosulfonyl)benzoyl chloride

: 1449429-06-4
ethyl 4-(2-amino-3-cyano-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

: 1449428-71-0
ethyl 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 1449428-71-0
ethyl 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 16 h / 120 °C

2: sulfuric acid / tetrahydrofuran / 48 h / 20 °C

3: sulfur; morpholine / ethanol / 2 h / Reflux

4: pyridine / dichloromethane / 20 °C

With morpholine; pyridine; sulfuric acid; potassium carbonate; sulfur; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 3: |Gewald Aminoheterocycles Synthesis;
DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

: 50-84-0
2,4 dichlorobenzoic acid

: 1449428-71-0
ethyl 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: chlorosulfonic acid / 16 h / 0 - 140 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.5 h / 20 °C

4: pyridine / dichloromethane / 20 °C

With pyridine; chlorosulfonic acid; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1016/j.ejmech.2013.05.013