ethyl 4-(2-amino-3-cyano-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

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Chemical Name:ethyl 4-(2-amino-3-cyano-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate
CAS No.:1449429-06-4
Molecular Formula:C₁₇H₁₇N₃O₂S
Molecular Weight:327.407
Hs Code.:

Synonyms:ethyl 4-(2-amino-3-cyano-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

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Chemical Property of ethyl 4-(2-amino-3-cyano-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

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Technology Process of ethyl 4-(2-amino-3-cyano-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

There total 4 articles about ethyl 4-(2-amino-3-cyano-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 25437-95-0
4-(4-Oxo-1-piperidinyl)benzoic acid ethyl ester

: 109-77-3
malononitrile

: 1449429-06-4
ethyl 4-(2-amino-3-cyano-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

Guidance literature:: With morpholine; sulfur; In ethanol; for 2h; Reflux;
DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 1449429-06-4
ethyl 4-(2-amino-3-cyano-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 16 h / 120 °C

2: sulfuric acid / tetrahydrofuran / 48 h / 20 °C

3: sulfur; morpholine / ethanol / 2 h / Reflux

With morpholine; sulfuric acid; potassium carbonate; sulfur; In tetrahydrofuran; ethanol; dimethyl sulfoxide; 3: |Gewald Aminoheterocycles Synthesis;
DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

: 79421-38-8
4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-benzoic acid ethyl ester

: 1449429-06-4
ethyl 4-(2-amino-3-cyano-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / tetrahydrofuran / 48 h / 20 °C

2: sulfur; morpholine / ethanol / 2 h / Reflux

With morpholine; sulfuric acid; sulfur; In tetrahydrofuran; ethanol; 2: |Gewald Aminoheterocycles Synthesis;
DOI:10.1016/j.ejmech.2013.05.013