(S)-2-tert-butyl-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxypyridine

Base Information

Chemical Name:(S)-2-tert-butyl-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxypyridine
CAS No.:1316312-43-2
Molecular Formula:C₂₄H₃₇NO₃Si
Molecular Weight:415.648
Hs Code.:

Synonyms:(S)-2-tert-butyl-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxypyridine

Suppliers and Price of (S)-2-tert-butyl-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxypyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-tert-butyl-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxypyridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-tert-butyl-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxypyridine

There total 4 articles about (S)-2-tert-butyl-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1191954-33-2,1191954-42-3
(S)-2-tert-butyl-6-[(tert-butyldimethylsilyloxy)phenylmethyl]-3-methoxypyridin-4(1H)-one

: 74-88-4
methyl iodide

: 1316312-43-2
(S)-2-tert-butyl-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxypyridine

Guidance literature:: (S)-2-tert-butyl-6-[(tert-butyldimethylsilyloxy)phenylmethyl]-3-methoxypyridin-4(1H)-one; With sodium hydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.3762/bjoc.7.108

Reference yield:

: C₂₃H₃₇NO₄Si

: 1316312-43-2
(S)-2-tert-butyl-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxypyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / Inert atmosphere; Reflux

2.1: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.3762/bjoc.7.108

Reference yield:

: 630-18-2
tert-butyl isocyanide

: 1316312-43-2
(S)-2-tert-butyl-6-[(tert-butyldimethylsiloxy)phenylmethyl]-3,4-dimethoxypyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / -40 °C / Inert atmosphere

1.2: Inert atmosphere; Cooling

1.3: 20 °C / Inert atmosphere; Cooling

2.1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / Inert atmosphere; Reflux

3.1: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.3762/bjoc.7.108