N-[(1R)-1-(2'-amino-3,3'-difluoro-1,1'-biphenyl-4-yl)ethyl]-1-[(trifluoroacetyl)amino]cyclopropanecarboxamide

Base Information

Chemical Name:N-[(1R)-1-(2'-amino-3,3'-difluoro-1,1'-biphenyl-4-yl)ethyl]-1-[(trifluoroacetyl)amino]cyclopropanecarboxamide
CAS No.:845830-45-7
Molecular Formula:C₂₀H₁₈F₅N₃O₂
Molecular Weight:427.374
Hs Code.:

Synonyms:N-[(1R)-1-(2'-amino-3,3'-difluoro-1,1'-biphenyl-4-yl)ethyl]-1-[(trifluoroacetyl)amino]cyclopropanecarboxamide

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Chemical Property of N-[(1R)-1-(2'-amino-3,3'-difluoro-1,1'-biphenyl-4-yl)ethyl]-1-[(trifluoroacetyl)amino]cyclopropanecarboxamide

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Technology Process of N-[(1R)-1-(2'-amino-3,3'-difluoro-1,1'-biphenyl-4-yl)ethyl]-1-[(trifluoroacetyl)amino]cyclopropanecarboxamide

There total 4 articles about N-[(1R)-1-(2'-amino-3,3'-difluoro-1,1'-biphenyl-4-yl)ethyl]-1-[(trifluoroacetyl)amino]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 845829-92-7
tert-butyl (1R)-1-(4-bromo-2-fluorophenyl)ethylcarbamate

: 845830-45-7
N-[(1R)-1-(2'-amino-3,3'-difluoro-1,1'-biphenyl-4-yl)ethyl]-1-[(trifluoroacetyl)amino]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethyl acetate

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 6 h

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 90 °C

4: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / 1,4-dioxane / 0.25 h / 90 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; potassium acetate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 845829-91-6
(1R)-(4-bromo-2-fluorophenyl)ethanamine hydrochloride

: 845830-45-7
N-[(1R)-1-(2'-amino-3,3'-difluoro-1,1'-biphenyl-4-yl)ethyl]-1-[(trifluoroacetyl)amino]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 6 h

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 90 °C

3: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / 1,4-dioxane / 0.25 h / 90 °C

With 1-hydroxy-7-aza-benzotriazole; potassium acetate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); dimethyl sulfoxide;

Reference yield:

: 669066-98-2
1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid

: 845830-45-7
N-[(1R)-1-(2'-amino-3,3'-difluoro-1,1'-biphenyl-4-yl)ethyl]-1-[(trifluoroacetyl)amino]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 6 h

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 90 °C

3: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / 1,4-dioxane / 0.25 h / 90 °C

With 1-hydroxy-7-aza-benzotriazole; potassium acetate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); dimethyl sulfoxide;