(2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)-N'-[(1E)-benzylidene]acrylohydrazide

Base Information

• Chemical Name: (2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)-N'-[(1E)-benzylidene]acrylohydrazide
• CAS No.: 1394115-35-5
• Molecular Formula: C₁₇H₁₅N₃O₅
• Molecular Weight: 341.323
• Mol file: 1394115-35-5.mol

Synonyms:(2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)-N'-[(1E)-benzylidene]acrylohydrazide

Chemical Property of (2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)-N'-[(1E)-benzylidene]acrylohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)-N'-[(1E)-benzylidene]acrylohydrazide

There total 2 articles about (2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)-N'-[(1E)-benzylidene]acrylohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)acrylohydrazide (1394115-41-3) + benzaldehyde (100-52-7) → (2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)-N'-[(1E)-benzylidene]acrylohydrazide (1394115-35-5)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 1h; Reflux;

DOI:10.1016/j.ejmech.2012.05.041

Reference yield:

isonitrovanillin (6635-20-7) → (2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)-N'-[(1E)-benzylidene]acrylohydrazide (1394115-35-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: piperidine; pyridine / 1 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 2 h / 20 °C

2.2: 0 - 10 °C

3.1: hydrogenchloride / ethanol; water / 1 h / Reflux

With piperidine; pyridine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; acetonitrile; 1.1: Knoevenagel-Doebner reaction;

DOI:10.1016/j.ejmech.2012.05.041

upstream raw materials:

(2E)-3-(4-hydroxy-3-methoxy-5-nitrophenyl)acrylohydrazide

benzaldehyde

isonitrovanillin