2-<(4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-1,3-oxazolidin-5-yl>-1,3-thiazole

Base Information

Chemical Name:2-<(4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-1,3-oxazolidin-5-yl>-1,3-thiazole
CAS No.:163010-80-8
Molecular Formula:C₁₉H₂₄N₂O₃S
Molecular Weight:360.477
Hs Code.:

Synonyms:2-<(4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-1,3-oxazolidin-5-yl>-1,3-thiazole

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Chemical Property of 2-<(4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-1,3-oxazolidin-5-yl>-1,3-thiazole

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Technology Process of 2-<(4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-1,3-oxazolidin-5-yl>-1,3-thiazole

There total 1 articles about 2-<(4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-1,3-oxazolidin-5-yl>-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77-76-9
2,2-dimethoxy-propane

: 2-<2-(N-tert-butoxycarbonylamino)-1-hydroxy-2-phenylethyl>-1,3-thiazole

: 2-<(4R,5S)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-1,3-oxazolidin-5-yl>-1,3-thiazole

: 163010-80-8
2-<(4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-1,3-oxazolidin-5-yl>-1,3-thiazole

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 80 ℃; for 8h; Title compound not separated from byproducts;
DOI:10.1055/s-1995-3882

Reference yield:

: 163010-80-8
2-<(4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-1,3-oxazolidin-5-yl>-1,3-thiazole

: 143615-03-6,143527-70-2
(4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) methyl triflate, 4 Angstroem molecular sieves; 2.) NaBH₄; 3.) HgCl₂ / 1.) MeCN, r.t., 30 min; 2.) MeOH, r.t., 10 min; 3.) MeCN/H₂O, 15 min, r.t.

2: KMnO₄, potassium phosphate / 2-methyl-propan-2-ol; H₂O / 0.25 h / Ambient temperature

With sodium tetrahydroborate; potassium phosphate; potassium permanganate; 4 A molecular sieve; methyl trifluoromethanesulfonate; mercury dichloride; In water; tert-butyl alcohol;
DOI:10.1055/s-1995-3882

Reference yield:

: 163010-80-8
2-<(4S,5R)-N-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-1,3-oxazolidin-5-yl>-1,3-thiazole

: 163010-82-0
(4S,5R)-5-Formyl-2,2-dimethyl-4-phenyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; 4 A molecular sieve; methyl trifluoromethanesulfonate; mercury dichloride; Yield given. Multistep reaction; 1.) MeCN, r.t., 30 min; 2.) MeOH, r.t., 10 min; 3.) MeCN/H₂O, 15 min, r.t.;
DOI:10.1055/s-1995-3882