2-Amino-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-4-(4-{[(2S)-2-hydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile

Base Information

Chemical Name:2-Amino-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-4-(4-{[(2S)-2-hydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile
CAS No.:1107662-73-6
Molecular Formula:C₂₇H₂₂FN₅O₃S
Molecular Weight:515.568
Hs Code.:

Synonyms:2-Amino-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-4-(4-{[(2S)-2-hydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile

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Chemical Property of 2-Amino-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-4-(4-{[(2S)-2-hydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile

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Technology Process of 2-Amino-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-4-(4-{[(2S)-2-hydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile

There total 3 articles about 2-Amino-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-4-(4-{[(2S)-2-hydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1107663-66-0
2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)pyridine-3,5-dicarbonitrile

: 1107662-73-6
2-Amino-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-4-(4-{[(2S)-2-hydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile

Guidance literature:: With hydrogenchloride; water; In methanol; at 20 ℃; for 12h;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1107662-73-6
2-Amino-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-4-(4-{[(2S)-2-hydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water; lithium chloride / tetrahydrofuran / 20 h / -30 - 20 °C

1.2: 20 h / 130 °C

2.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h / 20 °C

3.1: hydrogenchloride; water / methanol / 12 h / 20 °C

With hydrogenchloride; water; sodium hydrogencarbonate; lithium chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1107662-95-2
2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-mercaptopyridine-3,5-dicarbonitrile

: 625826-69-9
4-(chloromethyl)-2-(4-fluorophenyl)-5-methyl-1,3-oxazole

: 1107662-73-6
2-Amino-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-4-(4-{[(2S)-2-hydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 h / 20 °C

2: hydrogenchloride; water / methanol / 12 h / 20 °C

With hydrogenchloride; water; sodium hydrogencarbonate; In methanol; N,N-dimethyl-formamide;