2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-mercaptopyridine-3,5-dicarbonitrile

Base Information

• Chemical Name: 2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-mercaptopyridine-3,5-dicarbonitrile
• CAS No.: 1107662-95-2
• Molecular Formula: C₂₂H₂₈N₄O₂SSi
• Molecular Weight: 440.641

Synonyms:2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-mercaptopyridine-3,5-dicarbonitrile

Chemical Property of 2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-mercaptopyridine-3,5-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-mercaptopyridine-3,5-dicarbonitrile

There total 2 articles about 2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-mercaptopyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyanothioacetamide (7357-70-2) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + tert-butyldimethylsilyl chloride (18162-48-6) + (S)-Propylene oxide (16088-62-3) → 2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-mercaptopyridine-3,5-dicarbonitrile (1107662-95-2) + 2-amino-4-{4-[(1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy]phenyl}-6-mercaptopyridine-3,5-dicarbonitrile (1325717-31-4)

Guidance literature:

(S)-Propylene oxide; With hydrogenchloride; water; lithium chloride; In tetrahydrofuran; at -30 - 20 ℃; for 20h;

4-hydroxy-benzaldehyde; With sodium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 20h;

Cyanothioacetamide; tert-butyldimethylsilyl chloride;

Reference yield:

→ 2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-mercaptopyridine-3,5-dicarbonitrile (1107662-95-2)

Guidance literature:

With 4-methyl-morpholine; In ethanol; at 20 ℃; for 24h;

Reference yield: 57.0%

2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-mercaptopyridine-3,5-dicarbonitrile (1107662-95-2) + 4-(chloromethyl)-2-(4-fluorophenyl)-5-methyl-1,3-oxazole (625826-69-9) → 2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)pyridine-3,5-dicarbonitrile (1107663-66-0)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

upstream raw materials:

Cyanothioacetamide

4-hydroxy-benzaldehyde

tert-butyldimethylsilyl chloride

(S)-Propylene oxide

Downstream raw materials:

2-Amino-4-(4-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}propyl]oxy}phenyl)-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)pyridine-3,5-dicarbonitrile

2-Amino-6-({[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-4-(4-{[(2S)-2-hydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile

C₃₀H₃₆N₆O₃SSi

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