[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 1-(2-benzyloxy-1-hydroxy-ethyl)-2,2-difluoro-vinyl ester

Base Information

Chemical Name:[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 1-(2-benzyloxy-1-hydroxy-ethyl)-2,2-difluoro-vinyl ester
CAS No.:255715-04-9
Molecular Formula:C₃₃H₄₁F₂NO₅Si
Molecular Weight:597.775
Hs Code.:

[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 1-(2-benzyloxy-1-hydroxy-ethyl)-2,2-difluoro-vinyl ester

Synonyms:[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 1-(2-benzyloxy-1-hydroxy-ethyl)-2,2-difluoro-vinyl ester

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Chemical Property of [2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 1-(2-benzyloxy-1-hydroxy-ethyl)-2,2-difluoro-vinyl ester

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Technology Process of [2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 1-(2-benzyloxy-1-hydroxy-ethyl)-2,2-difluoro-vinyl ester

There total 5 articles about [2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 1-(2-benzyloxy-1-hydroxy-ethyl)-2,2-difluoro-vinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 60656-87-3
benzyloxyacetoaldehyde

: 255714-99-9
[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 2,2,2-trifluoro-ethyl ester

: 255715-04-9
[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 1-(2-benzyloxy-1-hydroxy-ethyl)-2,2-difluoro-vinyl ester

Guidance literature:: [2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 2,2,2-trifluoro-ethyl ester; With lithium diisopropyl amide; In tetrahydrofuran;

With magnesium bromide; In tetrahydrofuran;

benzyloxyacetoaldehyde; With boron trifluoride diethyl etherate; In tetrahydrofuran; at -30 - 0 ℃;
DOI:10.1039/a907174a

Reference yield:

: 109-56-8
i-propyl(2-(hydroxy)ethyl)amine

: 255715-04-9
[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 1-(2-benzyloxy-1-hydroxy-ethyl)-2,2-difluoro-vinyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: DMAP / CH₂Cl₂ / 12 h / Heating

2.1: Et₃N / CH₂Cl₂ / 16 h / 0 - 20 °C

3.1: tetrahydrofuran / 16 h / Heating

4.1: LDA / tetrahydrofuran

4.2: MgBr₂*OEt₂ / tetrahydrofuran

4.3: 71 percent / BF₃*Et₂O / tetrahydrofuran / -30 - 0 °C

With dmap; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Substitution / 2.1: Acylation / 3.1: Substitution / 4.1: Dehydrofluorination / 4.2: Addition / 4.3: Addition;
DOI:10.1039/a907174a

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 255715-04-9
[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid 1-(2-benzyloxy-1-hydroxy-ethyl)-2,2-difluoro-vinyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: DMAP / CH₂Cl₂ / 12 h / Heating

2.1: Et₃N / CH₂Cl₂ / 16 h / 0 - 20 °C

3.1: tetrahydrofuran / 16 h / Heating

4.1: LDA / tetrahydrofuran

4.2: MgBr₂*OEt₂ / tetrahydrofuran

4.3: 71 percent / BF₃*Et₂O / tetrahydrofuran / -30 - 0 °C

With dmap; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Substitution / 2.1: Acylation / 3.1: Substitution / 4.1: Dehydrofluorination / 4.2: Addition / 4.3: Addition;
DOI:10.1039/a907174a