Ac-Leu-2-Ala-Ser-Leu-Gly-OMe

Base Information

Chemical Name:Ac-Leu-2-Ala-Ser-Leu-Gly-OMe
CAS No.:107540-40-9
Molecular Formula:C₄₇H₇₂N₁₅O₁₇P
Molecular Weight:1150.15
Hs Code.:

Ac-Leu-<Arg(NO2)>2-Ala-Ser<OP(O)(OPh)2>-Leu-Gly-OMe

Synonyms:Ac-Leu-2-Ala-Ser-Leu-Gly-OMe

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ac-Leu-2-Ala-Ser-Leu-Gly-OMe

Chemical Property:

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Technology Process of Ac-Leu-2-Ala-Ser-Leu-Gly-OMe

There total 14 articles about Ac-Leu-2-Ala-Ser-Leu-Gly-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 107540-36-3
Ac-Leu-2-Ala

: 107540-39-6
{(S)-2-[(S)-2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; hydrochloride

: 107540-40-9
Ac-Leu-2-Ala-Ser-Leu-Gly-OMe

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) -10 deg C, 2 h, 2.) room temp., 18 h;
DOI:10.1021/jo00385a023

Reference yield:

: 5084-98-0,62188-57-2,109453-36-3
methyl N-benzyloxycarbonyl-L-leucylglicynate

: 107540-40-9
Ac-Leu-2-Ala-Ser-Leu-Gly-OMe

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / H₂, 2N HCl / Pd/C / methanol; ethanol / 18 h / 1551.4 Torr

2: 66 percent / 1-hydroxybenzotriazole (HOBt), N-methylmorpholine, dicyclohexylcarbodiimide (DCC) / dimethylformamide / 1.) -10 deg C, 1 h, 2.) room temp., 18 h

3: 94 percent / pyridine / 1.) -10 deg C, 2.5 h, 2.) 4 deg C, 18 h

4: 95 percent / H₂, 2N HCl / Pd/C / methanol; ethanol / 18 h / 1551.4 Torr

5: 65 percent / 1-hydroxybenzotriazole (HOBt), N-methylmorpholine, dicyclohexylcarbodiimide (DCC) / dimethylformamide / 1.) -10 deg C, 2 h, 2.) room temp., 18 h

With 4-methyl-morpholine; pyridine; hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00385a023

Reference yield:

: 107540-26-1
Z-Ser-Leu-Gly-OMe

: 107540-40-9
Ac-Leu-2-Ala-Ser-Leu-Gly-OMe

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / pyridine / 1.) -10 deg C, 2.5 h, 2.) 4 deg C, 18 h

2: 95 percent / H₂, 2N HCl / Pd/C / methanol; ethanol / 18 h / 1551.4 Torr

3: 65 percent / 1-hydroxybenzotriazole (HOBt), N-methylmorpholine, dicyclohexylcarbodiimide (DCC) / dimethylformamide / 1.) -10 deg C, 2 h, 2.) room temp., 18 h

With 4-methyl-morpholine; pyridine; hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00385a023