[1-(biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid

Base Information

Chemical Name:[1-(biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid
CAS No.:1333331-52-4
Molecular Formula:C₁₇H₁₄BNO₄
Molecular Weight:307.113
Hs Code.:

Synonyms:[1-(biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid

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Chemical Property of [1-(biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid

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Technology Process of [1-(biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid

There total 7 articles about [1-(biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1333331-83-1
dimethyl [5-(benzyloxy)-1-(biphenyl-3-yl)-4-oxo-1,4-dihydropyridin-3-yl]boronate

: 1333331-52-4
[1-(biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid

Guidance literature:: dimethyl [5-(benzyloxy)-1-(biphenyl-3-yl)-4-oxo-1,4-dihydropyridin-3-yl]boronate; With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; for 18h; under 760.051 Torr;

With hydrogenchloride; In water; N,N-dimethyl-formamide;
DOI:10.1021/ml500502d

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 1333331-52-4
[1-(biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water; methanol / 4.5 h / Reflux

2.1: Jones reagent / acetone / 0 - 25 °C

3.1: diphenylether / 0.17 h / 250 °C

4.1: N-Bromosuccinimide / acetic acid / 1 h / 18 - 25 °C

5.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / -10 - 25 °C

5.2: 3.5 h

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 18 h

With N-Bromosuccinimide; Jones reagent; hydrogen; isopropylmagnesium chloride; lithium chloride; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diphenylether; water; acetic acid; acetone;

Reference yield:

: 1333331-70-6
3-(benzyloxy)-1-(biphenyl-3-yl)pyridin-4(1H)-one

: 1333331-52-4
[1-(biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / acetic acid / 1 h / 18 - 25 °C

2.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / -10 - 25 °C

2.2: 3.5 h

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 18 h

With N-Bromosuccinimide; hydrogen; isopropylmagnesium chloride; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; acetic acid;