3,4-dihydro-3,3-dimethyl-4-oxonaphthalene-1-carboxylic acid S-(-)-N-methyl-1-phenyl ethylamide

Base Information

Chemical Name:3,4-dihydro-3,3-dimethyl-4-oxonaphthalene-1-carboxylic acid S-(-)-N-methyl-1-phenyl ethylamide
CAS No.:945670-33-7
Molecular Formula:C₂₂H₂₃NO₂
Molecular Weight:333.43
Hs Code.:

Synonyms:3,4-dihydro-3,3-dimethyl-4-oxonaphthalene-1-carboxylic acid S-(-)-N-methyl-1-phenyl ethylamide

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Chemical Property of 3,4-dihydro-3,3-dimethyl-4-oxonaphthalene-1-carboxylic acid S-(-)-N-methyl-1-phenyl ethylamide

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Technology Process of 3,4-dihydro-3,3-dimethyl-4-oxonaphthalene-1-carboxylic acid S-(-)-N-methyl-1-phenyl ethylamide

There total 5 articles about 3,4-dihydro-3,3-dimethyl-4-oxonaphthalene-1-carboxylic acid S-(-)-N-methyl-1-phenyl ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2977-45-9
2,2-dimethyl-3,4-dihydro-2H-naphthalen-1-one

: 945670-33-7
3,4-dihydro-3,3-dimethyl-4-oxonaphthalene-1-carboxylic acid S-(-)-N-methyl-1-phenyl ethylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-butylhydroperoxide; chromic oxide / CH₂Cl₂; H₂O / 96 h

2.1: LDA / tetrahydrofuran / 1.5 h / -78 °C

2.2: tetrahydrofuran / 2 h / 20 °C

3.1: triphenylphosphine / Pd(OAc)2 / CH₂Cl₂

With chromium(VI) oxide; tert.-butylhydroperoxide; triphenylphosphine; lithium diisopropyl amide; palladium diacetate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/b702572f

Reference yield:

: 254981-70-9
2,2-dimethyl-2,3-dihydronaphthalene-1,4-dione

: 945670-33-7
3,4-dihydro-3,3-dimethyl-4-oxonaphthalene-1-carboxylic acid S-(-)-N-methyl-1-phenyl ethylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / 1.5 h / -78 °C

1.2: tetrahydrofuran / 2 h / 20 °C

2.1: triphenylphosphine / Pd(OAc)2 / CH₂Cl₂

With triphenylphosphine; lithium diisopropyl amide; palladium diacetate; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b702572f

Reference yield:

: 254981-71-0
C₁₃H₁₁F₃O₄S

: 945670-33-7
3,4-dihydro-3,3-dimethyl-4-oxonaphthalene-1-carboxylic acid S-(-)-N-methyl-1-phenyl ethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.33 g / triphenylphosphine; diisopropylethylamine / Pd(OAc)2 / dimethylformamide / 9 h

2: aq. LiOH / methanol

3: EDC; 4-dimethylaminopyridine

With dmap; lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium diacetate; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/b702572f