(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

Base Information

Chemical Name:(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide
CAS No.:1588490-10-1
Molecular Formula:C₁₈H₂₅N₃OSn
Molecular Weight:418.126
Hs Code.:

Synonyms:(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

Chemical Property:

Purity/Quality:

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Technology Process of (R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

There total 10 articles about (R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.8%

: 1588490-09-8
(R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

: 661-69-8
hexamethyldistannane

: 1588490-10-1
(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; Reflux;

Reference yield:

: 1586033-67-1
N-(α-methyl-4-iodobenzyl)-N-formyl-C-formylglycine methyl ester

: 1588490-10-1
(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / methanol; water / 2 h / 60 °C

2.1: sodium nitrite; nitric acid / water; tetrachloromethane / 35 - 50 °C

3.1: sodium hydroxide / 5 h / Reflux

4.1: triethylamine; phosphorous acid trimethyl ester; iodine / dichloromethane / 0.17 h / Cooling with ice

4.2: 3 h / 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; nitric acid; triethylamine; sodium hydroxide; sodium nitrite; phosphorous acid trimethyl ester; In methanol; tetrachloromethane; dichloromethane; water; toluene;

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1588490-10-1
(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1,2-dichloro-ethane / 1.5 h / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: sodium hydroxide / methanol

3.1: potassium carbonate / acetonitrile / 16 h / Reflux; Inert atmosphere

4.1: toluene / 3 h / Reflux; Dean-Stark

5.1: sodium methylate / toluene / 16 h / 20 °C / Cooling

6.1: hydrogenchloride / methanol; water / 2 h / 60 °C

7.1: sodium nitrite; nitric acid / water; tetrachloromethane / 35 - 50 °C

8.1: sodium hydroxide / 5 h / Reflux

9.1: triethylamine; phosphorous acid trimethyl ester; iodine / dichloromethane / 0.17 h / Cooling with ice

9.2: 3 h / 20 °C

10.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; nitric acid; sodium methylate; potassium carbonate; triethylamine; sodium hydroxide; sodium nitrite; phosphorous acid trimethyl ester; In methanol; tetrachloromethane; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile;