(R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

Base Information

Chemical Name:(R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide
CAS No.:1588490-09-8
Molecular Formula:C₁₅H₁₆IN₃O
Molecular Weight:381.216
Hs Code.:

Synonyms:(R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

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Chemical Property of (R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

Chemical Property:

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Technology Process of (R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

There total 9 articles about (R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.9%

: 503-29-7
azetidine

: 1586033-69-3
(R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid

: 1588490-09-8
(R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

Guidance literature:: (R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid; With iodine; triethylamine; phosphorous acid trimethyl ester; In dichloromethane; for 0.166667h; Cooling with ice;

azetidine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1586033-67-1
N-(α-methyl-4-iodobenzyl)-N-formyl-C-formylglycine methyl ester

: 1588490-09-8
(R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol; water / 2 h / 60 °C

2.1: sodium nitrite; nitric acid / water; tetrachloromethane / 35 - 50 °C

3.1: sodium hydroxide / 5 h / Reflux

4.1: triethylamine; phosphorous acid trimethyl ester; iodine / dichloromethane / 0.17 h / Cooling with ice

4.2: 3 h / 20 °C

With hydrogenchloride; iodine; nitric acid; triethylamine; sodium hydroxide; sodium nitrite; phosphorous acid trimethyl ester; In methanol; tetrachloromethane; dichloromethane; water;

Reference yield:

: 1586033-68-2
N-(α-methyl-4-iodobenzyl)-2-mercaptoimidazole-5-carboxylic acid methyl ester

: 1588490-09-8
(R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid azetidinylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; nitric acid / water; tetrachloromethane / 35 - 50 °C

2.1: sodium hydroxide / 5 h / Reflux

3.1: triethylamine; phosphorous acid trimethyl ester; iodine / dichloromethane / 0.17 h / Cooling with ice

3.2: 3 h / 20 °C

With iodine; nitric acid; triethylamine; sodium hydroxide; sodium nitrite; phosphorous acid trimethyl ester; In tetrachloromethane; dichloromethane; water;