(2R)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole

Base Information

Chemical Name:(2R)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole
CAS No.:219923-96-3
Molecular Formula:C₁₃H₁₂BrF₂N₃O₂
Molecular Weight:360.158
Hs Code.:

Synonyms:(2R)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole

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Chemical Property of (2R)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole

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Technology Process of (2R)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole

There total 5 articles about (2R)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 118689-07-9
(S)-(+)-2(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol

: 219923-96-3
(2R)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole

: 219923-97-4
(2S)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole

: (2R-cis)-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole

Guidance literature:: With methanesulfonic acid; In dichloromethane; at 10 - 20 ℃;
DOI:10.1021/jm0494772

Reference yield:

: 86404-63-9
1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

: 219923-96-3
(2R)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH; N-benzyltriethylammonium chloride / toluene / 24 h / Heating

2: aq. H₂SO₄ / 20 °C

3: 11 percent / methanesulfonic acid / CH₂Cl₂ / 10 - 20 °C

With sodium hydroxide; methanesulfonic acid; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; toluene;
DOI:10.1021/jm0494772

Reference yield:

: 2-(2,4-difluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propionitrile

: 219923-96-3
(2R)-cis-1-[[2-(bromomethyl)-4-(2,4-difluorophenyl)-1,3-dioxolan-4-yl]methyl]-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / aq. HCl / 20 h / Heating

2: 87 percent / LiAlH₄ / tetrahydrofuran / 24 h

3: 11 percent / methanesulfonic acid / CH₂Cl₂ / 10 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; methanesulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0494772